Antitumor effects of dammarane-type saponins from steamed Notoginseng

Six dammarane-type saponins were extracted from steamed Panax notoginseng. Their chemical structures were identified spectroscopically as ginsenosides Rh1 (1), Rg1 (2), 20 (S)-Rg3 (3), 20 (R)-Rg3 (4), Rb3 (5), and Rb1 (6). Compounds (0.1-10 μM) were tested for inhibition of tumor necrosis factor-α (...

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Bibliographic Details
Published in:Pharmacognosy Magazine 2014-07, Vol.10 (39), p.314-317
Main Authors: He, Fan, Ding, Yan, Liang, Chun, Song, Seok Bean, Dou, De-Qiang, Song, Gyu Yong, Kim, Young Ho
Format: Article
Language:English
Subjects:
Care and treatment
Chemical properties
Chromatography
Deoxyribonucleic acid
DNA
Genes
Health aspects
Medicinal plants
Natural products
Nitric oxide
NMR
Notoginseng
Nuclear magnetic resonance
Original
Particle size
Polymerase chain reaction
Saponins
Signal transduction
Tumors
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Summary:Six dammarane-type saponins were extracted from steamed Panax notoginseng. Their chemical structures were identified spectroscopically as ginsenosides Rh1 (1), Rg1 (2), 20 (S)-Rg3 (3), 20 (R)-Rg3 (4), Rb3 (5), and Rb1 (6). Compounds (0.1-10 μM) were tested for inhibition of tumor necrosis factor-α (TNF)-induced nuclear factor kappa-light-chain-enhancer of activated B cells (NF-κB) luciferase reporter activity using a human kidney 293T cell-based assay. Ginsenoside Rb3 (5) showed the most significant activity with an IC50 of 8.2 μM. This compound also inhibited the induction of cyclooxygenase-2 (COX-2) and inducible nitric oxide synthase (iNOS) messenger Ribonucleic acid (mRNA) in a dose-dependent manner after HepG2 cells had been treated with TNF-α (10 ng/mL).
ISSN:0973-1296
0976-4062
DOI:10.4103/0973-1296.137372