Curvature effect on hemodynamic conditions at the inner bend of the carotid siphon and its relation to aneurysm formation

Abstract Although high-impact hemodynamic forces are thought to lead to cerebral aneurysmal change, little is known about the aneurysm formation on the inner aspect of vascular bends such as the internal carotid artery (ICA) siphon where wall shear stress (WSS) is expected to be low. This study eval...

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Bibliographic Details
Published in:Journal of biomechanics 2014-09, Vol.47 (12), p.3018-3027
Main Authors: Lauric, Alexandra, Hippelheuser, James, Safain, Mina G, Malek, Adel M
Format: Article
Language:English
Subjects:
Adult
Aged
Aged, 80 and over
Aneurysm formation
Aneurysms
Carotid Artery, Internal - physiology
Computational fluid dynamics
Computer simulation
Curvature
Female
Formations
Hemodynamics
Humans
Hypertension
Internal carotid artery
Intracranial aneurysm
Intracranial Aneurysm - physiopathology
Male
Mathematical analysis
Mathematical models
Medical imaging
Middle Aged
Models, Cardiovascular
Mortality
Patients
Physical Medicine and Rehabilitation
Shear stress
Siphons
Software
Stress, Mechanical
Studies
Vessel curvature
Young Adult
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Summary:Abstract Although high-impact hemodynamic forces are thought to lead to cerebral aneurysmal change, little is known about the aneurysm formation on the inner aspect of vascular bends such as the internal carotid artery (ICA) siphon where wall shear stress (WSS) is expected to be low. This study evaluates the effect of vessel curvature and hemodynamics on aneurysm formation along the inner carotid siphon. Catheter 3D-rotational angiographic volumes of 35 ICA (10 aneurysms, 25 controls) were evaluated in 3D for radius of curvature and peak curvature of the siphon bend, followed by univariate statistical analysis. Computational fluid dynamic (CFD) simulations were performed on patient-derived models after aneurysm removal and on synthetic variants of increasing curvature. Peak focal siphon curvature was significantly higher in aneurysm bearing ICAs (0.36±0.045 vs. 0.30±0.048 mm−1 , p =0.003), with no difference in global radius of curvature ( p =0.36). In CFD simulations, increasing parametric curvature tightness (from 5 to 3 mm radius) resulted in dramatic increase of WSS and WSS gradient magnitude (WSSG) on the inner wall of the bend. In patient-derived data, the location of aneurysms coincided with regions of low WSS (
ISSN:0021-9290
1873-2380
DOI:10.1016/j.jbiomech.2014.06.042