Microbiological features of KPC-producing Enterobacter isolates identified in a U.S. hospital system

Abstract Microbiological data regarding Klebsiella pneumoniae carbapenemase (KPC)–producing Enterobacter spp. are scarce. In this study, 11 unique KPC-producing Enterobacter isolates were identified among 44 ertapenem-nonsusceptible Enterobacter isolates collected between 2009 and 2013 at a hospital...

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Bibliographic Details
Published in:Diagnostic microbiology and infectious disease 2014-10, Vol.80 (2), p.154-158
Main Authors: Ahn, Chulsoo, Syed, Alveena, Hu, Fupin, O’Hara, Jessica A, Rivera, Jesabel I, Doi, Yohei
Format: Article
Language:English
Subjects:
Adult
Aged
Anti-Bacterial Agents - pharmacology
Bacterial Proteins - secretion
beta-Lactam Resistance
beta-Lactamases - secretion
beta-Lactams - pharmacology
Cross Infection - epidemiology
Cross Infection - microbiology
Electrophoresis, Gel, Pulsed-Field
Enterobacter aerogenes
Enterobacter cloacae
Enterobacter cloacae - classification
Enterobacter cloacae - enzymology
Enterobacter cloacae - genetics
Enterobacter cloacae - isolation & purification
Enterobacteriaceae Infections - epidemiology
Enterobacteriaceae Infections - microbiology
Female
Genotype
Hospitals
Humans
Infectious Disease
Internal Medicine
Klebsiella pneumoniae carbapenemease
Male
Microbial Sensitivity Tests
Middle Aged
Molecular Epidemiology
Multilocus Sequence Typing
Pennsylvania - epidemiology
Plasmids - analysis
Young Adult
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Summary:Abstract Microbiological data regarding Klebsiella pneumoniae carbapenemase (KPC)–producing Enterobacter spp. are scarce. In this study, 11 unique KPC-producing Enterobacter isolates were identified among 44 ertapenem-nonsusceptible Enterobacter isolates collected between 2009 and 2013 at a hospital system in Western Pennsylvania. All cases were healthcare-associated and occurred in medically complex patients. While pulsed-field gel electrophoresis showed diverse restriction patterns overall, multilocus sequence typing identified Enterobacter cloacae isolates with sequence types 93 and 171 from 2 hospitals each. The levels of carbapenem minimum inhibitory concentrations were highly variable. All isolates remained susceptible to colistin and tigecycline, and the majority, to amikacin and doxycycline. A blaKPC -carrying IncN plasmid conferring trimethoprim-sulfamethoxazole resistance was identified in 3 of the isolates. Spread of blaKPC in Enterobacter spp. appears to be due to a combination of plasmid-mediated and clonal processes.
ISSN:0732-8893
1879-0070
DOI:10.1016/j.diagmicrobio.2014.06.010