Comparative in vitro cytotoxic studies of novel 8-(4′/2′-Methoxy/Unsubstituted phenylcarbamoyl)bicyclo[3.3.1]nonane derivatives on ehrlich ascites carcinoma cell line

Novel bicyclo[3.3.1]nonane derivatives were synthesized by an efficient methodology from acetoacetanilide, 2-methoxy and 4-methoxyacetoacetanilides, 1,3,5-trinitrobenzene and triethylamine. The structures of the compounds were characterized by UV/Visible, FTIR, 1 H NMR and 2D-correlation spectroscop...

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Bibliographic Details
Published in:Indian journal of pharmaceutical sciences 2014-07, Vol.76 (4), p.370-374
Main Authors: Chandrasekaran, Dhivya, Vandarkuzhali, SAA, Sridharan, G, Natarajan, Radha, Brindha, P
Format: Article
Language:English
Subjects:
Alkanes
Cancer
Carcinoma
Care and treatment
Cytotoxicity
Derivatives
Drugs
Ethanol
Medical research
Pharmacology, Experimental
Properties
Short Communications
Structure-activity relationship (Pharmacology)
Structure-activity relationships
Studies
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Summary:Novel bicyclo[3.3.1]nonane derivatives were synthesized by an efficient methodology from acetoacetanilide, 2-methoxy and 4-methoxyacetoacetanilides, 1,3,5-trinitrobenzene and triethylamine. The structures of the compounds were characterized by UV/Visible, FTIR, 1 H NMR and 2D-correlation spectroscopy analysis. The in vitro cytotoxic studies were performed using Ehrlich Ascites Carcinoma cell line by Trypan blue dye exclusion assay and 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide cell proliferation assay. The IC 50 values of the 8-(4′-/2′-methoxy/unsubstituted phenylcarbamoyl)bicyclo[3.3.1]nonanes were found to be 110.65 µg/ml, 148.23 µg/ml and 151.71 µg/ml, respectively. Thus (4-methoxyphenylcarbomyl)bicyclo[3.3.1]nonane was more potent compared to other two bicyclic adducts.
ISSN:0250-474X
1998-3743