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Sleep duration is associated with white matter hyperintensity volume in older adults: the Northern Manhattan Study
Summary Self‐reports of long or short sleep durations have indicated an association with cardiovascular morbidity and mortality, but there are limited data evaluating their association with white matter hyperintensity volume (WMHV), a marker of cerebral small vessel disease. We conducted a cross‐sec...
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| Published in: | Journal of sleep research 2014-10, Vol.23 (5), p.524-530 |
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| cites | cdi_FETCH-LOGICAL-c4857-4f9b2d1b5fcd1e822420d814ecf430a14d3f4abcf51b8fd8c4833e353a73150b3 |
| container_end_page | 530 |
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| container_title | Journal of sleep research |
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| creator | Ramos, Alberto R. Dong, Chuanhui Rundek, Tatjana Elkind, Mitchell S. V. Boden‐Albala, Bernadette Sacco, Ralph L. Wright, Clinton B. |
| description | Summary
Self‐reports of long or short sleep durations have indicated an association with cardiovascular morbidity and mortality, but there are limited data evaluating their association with white matter hyperintensity volume (WMHV), a marker of cerebral small vessel disease. We conducted a cross‐sectional analysis of self‐reported sleep duration to test for a correlation with white matter hyperintensities, measured by quantitative magnetic resonance imaging (MRI), in the Northern Manhattan Study. We used multivariable linear regression models to assess associations between both short ( |
| doi_str_mv | 10.1111/jsr.12177 |
| format | article |
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Self‐reports of long or short sleep durations have indicated an association with cardiovascular morbidity and mortality, but there are limited data evaluating their association with white matter hyperintensity volume (WMHV), a marker of cerebral small vessel disease. We conducted a cross‐sectional analysis of self‐reported sleep duration to test for a correlation with white matter hyperintensities, measured by quantitative magnetic resonance imaging (MRI), in the Northern Manhattan Study. We used multivariable linear regression models to assess associations between both short (<6 h) and long (≥9 h) sleep durations and log‐transformed WMHV, adjusting for demographic, behavioural and vascular risk factors. A total of 1244 participants, mean age 70 ± 9 years, 61% women and 68% Hispanics were analysed with magnetic resonance brain imaging and self‐reported sleep duration. Short sleep was reported by 23% (n = 293) and long sleep by 10% (n = 121) of the sample. Long sleep (β = 0.178; P = 0.035), but not short sleep (β = −0.053; P = 0.357), was associated with greater log‐WMHV in fully adjusted models. We observed an interaction between sleep duration, diabetes mellitus and log‐WMHV (P = 0.07). In fully adjusted models, stratified analysis showed that long sleep duration was associated with greater WMHV only in those with diabetes (β = 0.78; P = 0.0314), but not in those without diabetes (β = 0.022; P = 0.2), whereas short sleep was not associated with white matter hyperintensities in those with or without diabetes. In conclusion, long sleep duration was associated with a greater burden of white matter lesions in this stroke‐free urban sample. The association was seen mainly among those with diabetes mellitus.</description><identifier>ISSN: 0962-1105</identifier><identifier>EISSN: 1365-2869</identifier><identifier>DOI: 10.1111/jsr.12177</identifier><identifier>PMID: 25040435</identifier><language>eng</language><publisher>England</publisher><subject>Adult ; Aged ; Aging - pathology ; Cohort Studies ; diabetes ; Diabetes Mellitus - epidemiology ; Diabetes Mellitus - pathology ; elderly ; Female ; Hispanic Americans ; Humans ; hyperintensities ; leukoaraiosis ; long sleep ; Magnetic Resonance Imaging ; Male ; Middle Aged ; multi‐ethnic ; New York City - epidemiology ; Prevalence ; Risk Factors ; Self Report ; short sleep ; Sleep - physiology ; Stroke ; Time Factors ; white matter ; White Matter - pathology</subject><ispartof>Journal of sleep research, 2014-10, Vol.23 (5), p.524-530</ispartof><rights>2014 European Sleep Research Society</rights><rights>2014 European Sleep Research Society.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c4857-4f9b2d1b5fcd1e822420d814ecf430a14d3f4abcf51b8fd8c4833e353a73150b3</citedby><cites>FETCH-LOGICAL-c4857-4f9b2d1b5fcd1e822420d814ecf430a14d3f4abcf51b8fd8c4833e353a73150b3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>230,314,780,784,885,27923,27924</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/25040435$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Ramos, Alberto R.</creatorcontrib><creatorcontrib>Dong, Chuanhui</creatorcontrib><creatorcontrib>Rundek, Tatjana</creatorcontrib><creatorcontrib>Elkind, Mitchell S. V.</creatorcontrib><creatorcontrib>Boden‐Albala, Bernadette</creatorcontrib><creatorcontrib>Sacco, Ralph L.</creatorcontrib><creatorcontrib>Wright, Clinton B.</creatorcontrib><title>Sleep duration is associated with white matter hyperintensity volume in older adults: the Northern Manhattan Study</title><title>Journal of sleep research</title><addtitle>J Sleep Res</addtitle><description>Summary
Self‐reports of long or short sleep durations have indicated an association with cardiovascular morbidity and mortality, but there are limited data evaluating their association with white matter hyperintensity volume (WMHV), a marker of cerebral small vessel disease. We conducted a cross‐sectional analysis of self‐reported sleep duration to test for a correlation with white matter hyperintensities, measured by quantitative magnetic resonance imaging (MRI), in the Northern Manhattan Study. We used multivariable linear regression models to assess associations between both short (<6 h) and long (≥9 h) sleep durations and log‐transformed WMHV, adjusting for demographic, behavioural and vascular risk factors. A total of 1244 participants, mean age 70 ± 9 years, 61% women and 68% Hispanics were analysed with magnetic resonance brain imaging and self‐reported sleep duration. Short sleep was reported by 23% (n = 293) and long sleep by 10% (n = 121) of the sample. Long sleep (β = 0.178; P = 0.035), but not short sleep (β = −0.053; P = 0.357), was associated with greater log‐WMHV in fully adjusted models. We observed an interaction between sleep duration, diabetes mellitus and log‐WMHV (P = 0.07). In fully adjusted models, stratified analysis showed that long sleep duration was associated with greater WMHV only in those with diabetes (β = 0.78; P = 0.0314), but not in those without diabetes (β = 0.022; P = 0.2), whereas short sleep was not associated with white matter hyperintensities in those with or without diabetes. In conclusion, long sleep duration was associated with a greater burden of white matter lesions in this stroke‐free urban sample. The association was seen mainly among those with diabetes mellitus.</description><subject>Adult</subject><subject>Aged</subject><subject>Aging - pathology</subject><subject>Cohort Studies</subject><subject>diabetes</subject><subject>Diabetes Mellitus - epidemiology</subject><subject>Diabetes Mellitus - pathology</subject><subject>elderly</subject><subject>Female</subject><subject>Hispanic Americans</subject><subject>Humans</subject><subject>hyperintensities</subject><subject>leukoaraiosis</subject><subject>long sleep</subject><subject>Magnetic Resonance Imaging</subject><subject>Male</subject><subject>Middle Aged</subject><subject>multi‐ethnic</subject><subject>New York City - epidemiology</subject><subject>Prevalence</subject><subject>Risk Factors</subject><subject>Self Report</subject><subject>short sleep</subject><subject>Sleep - physiology</subject><subject>Stroke</subject><subject>Time Factors</subject><subject>white matter</subject><subject>White Matter - pathology</subject><issn>0962-1105</issn><issn>1365-2869</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2014</creationdate><recordtype>article</recordtype><recordid>eNp1kU1v1DAQhi0EokvhwB9APsIhrSe2kywHJFTxqQISC2fLiSfElWNvbaer_HsMWyo4MJc5zDPPWH4JeQrsDEqdX6V4BjW07T2yAd7Iqu6a7X2yYdumrgCYPCGPUrpiDFrJtw_JSS2ZYILLDYk7h7inZok62-CpTVSnFAarMxp6sHmih8lmpLPOGSOd1j1G6zP6ZPNKb4JbZqTW0-BMGWuzuJxe0jwh_RxiadHTT9pPZVt7usuLWR-TB6N2CZ_c9lPy_e2bbxfvq8sv7z5cvL6sBtHJthLjtq8N9HIcDGBX16JmpgOBwyg40yAMH4Xuh1FC342mK1ucI5dctxwk6_kpeXX07pd-RjOgz1E7tY921nFVQVv178TbSf0IN0qUnxQSiuD5rSCG6wVTVrNNAzqnPYYlKZBNA6ztGl7QF0d0iCGliOPdGWDqV0aqZKR-Z1TYZ3-_6478E0oBzo_AwTpc_29SH3dfj8qflvSfFg</recordid><startdate>201410</startdate><enddate>201410</enddate><creator>Ramos, Alberto R.</creator><creator>Dong, Chuanhui</creator><creator>Rundek, Tatjana</creator><creator>Elkind, Mitchell S. V.</creator><creator>Boden‐Albala, Bernadette</creator><creator>Sacco, Ralph L.</creator><creator>Wright, Clinton B.</creator><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>5PM</scope></search><sort><creationdate>201410</creationdate><title>Sleep duration is associated with white matter hyperintensity volume in older adults: the Northern Manhattan Study</title><author>Ramos, Alberto R. ; Dong, Chuanhui ; Rundek, Tatjana ; Elkind, Mitchell S. V. ; Boden‐Albala, Bernadette ; Sacco, Ralph L. ; Wright, Clinton B.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c4857-4f9b2d1b5fcd1e822420d814ecf430a14d3f4abcf51b8fd8c4833e353a73150b3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2014</creationdate><topic>Adult</topic><topic>Aged</topic><topic>Aging - pathology</topic><topic>Cohort Studies</topic><topic>diabetes</topic><topic>Diabetes Mellitus - epidemiology</topic><topic>Diabetes Mellitus - pathology</topic><topic>elderly</topic><topic>Female</topic><topic>Hispanic Americans</topic><topic>Humans</topic><topic>hyperintensities</topic><topic>leukoaraiosis</topic><topic>long sleep</topic><topic>Magnetic Resonance Imaging</topic><topic>Male</topic><topic>Middle Aged</topic><topic>multi‐ethnic</topic><topic>New York City - epidemiology</topic><topic>Prevalence</topic><topic>Risk Factors</topic><topic>Self Report</topic><topic>short sleep</topic><topic>Sleep - physiology</topic><topic>Stroke</topic><topic>Time Factors</topic><topic>white matter</topic><topic>White Matter - pathology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Ramos, Alberto R.</creatorcontrib><creatorcontrib>Dong, Chuanhui</creatorcontrib><creatorcontrib>Rundek, Tatjana</creatorcontrib><creatorcontrib>Elkind, Mitchell S. V.</creatorcontrib><creatorcontrib>Boden‐Albala, Bernadette</creatorcontrib><creatorcontrib>Sacco, Ralph L.</creatorcontrib><creatorcontrib>Wright, Clinton B.</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Journal of sleep research</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Ramos, Alberto R.</au><au>Dong, Chuanhui</au><au>Rundek, Tatjana</au><au>Elkind, Mitchell S. V.</au><au>Boden‐Albala, Bernadette</au><au>Sacco, Ralph L.</au><au>Wright, Clinton B.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Sleep duration is associated with white matter hyperintensity volume in older adults: the Northern Manhattan Study</atitle><jtitle>Journal of sleep research</jtitle><addtitle>J Sleep Res</addtitle><date>2014-10</date><risdate>2014</risdate><volume>23</volume><issue>5</issue><spage>524</spage><epage>530</epage><pages>524-530</pages><issn>0962-1105</issn><eissn>1365-2869</eissn><abstract>Summary
Self‐reports of long or short sleep durations have indicated an association with cardiovascular morbidity and mortality, but there are limited data evaluating their association with white matter hyperintensity volume (WMHV), a marker of cerebral small vessel disease. We conducted a cross‐sectional analysis of self‐reported sleep duration to test for a correlation with white matter hyperintensities, measured by quantitative magnetic resonance imaging (MRI), in the Northern Manhattan Study. We used multivariable linear regression models to assess associations between both short (<6 h) and long (≥9 h) sleep durations and log‐transformed WMHV, adjusting for demographic, behavioural and vascular risk factors. A total of 1244 participants, mean age 70 ± 9 years, 61% women and 68% Hispanics were analysed with magnetic resonance brain imaging and self‐reported sleep duration. Short sleep was reported by 23% (n = 293) and long sleep by 10% (n = 121) of the sample. Long sleep (β = 0.178; P = 0.035), but not short sleep (β = −0.053; P = 0.357), was associated with greater log‐WMHV in fully adjusted models. We observed an interaction between sleep duration, diabetes mellitus and log‐WMHV (P = 0.07). In fully adjusted models, stratified analysis showed that long sleep duration was associated with greater WMHV only in those with diabetes (β = 0.78; P = 0.0314), but not in those without diabetes (β = 0.022; P = 0.2), whereas short sleep was not associated with white matter hyperintensities in those with or without diabetes. In conclusion, long sleep duration was associated with a greater burden of white matter lesions in this stroke‐free urban sample. The association was seen mainly among those with diabetes mellitus.</abstract><cop>England</cop><pmid>25040435</pmid><doi>10.1111/jsr.12177</doi><tpages>7</tpages><oa>free_for_read</oa></addata></record> |
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| source | Wiley |
| subjects | Adult Aged Aging - pathology Cohort Studies diabetes Diabetes Mellitus - epidemiology Diabetes Mellitus - pathology elderly Female Hispanic Americans Humans hyperintensities leukoaraiosis long sleep Magnetic Resonance Imaging Male Middle Aged multi‐ethnic New York City - epidemiology Prevalence Risk Factors Self Report short sleep Sleep - physiology Stroke Time Factors white matter White Matter - pathology |
| title | Sleep duration is associated with white matter hyperintensity volume in older adults: the Northern Manhattan Study |
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