Forward and Backward Wave Morphology and Central Pressure Augmentation in Men and Women in the Framingham Heart Study

Central pressure augmentation is associated with greater backward wave amplitude and shorter transit time and is higher in women for reasons only partially elucidated. Augmentation also is affected by left ventricular function and shapes of the forward and backward waves. The goal of this study was...

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Published in:Hypertension (Dallas, Tex. 1979) Tex. 1979), 2014-08, Vol.64 (2), p.259-265
Main Authors: Torjesen, Alyssa A, Wang, Na, Larson, Martin G, Hamburg, Naomi M, Vita, Joseph A, Levy, Daniel, Benjamin, Emelia J, Vasan, Ramachandran S, Mitchell, Gary F
Format: Article
Language:English
Subjects:
Adult
Aged
Aged, 80 and over
Aging - physiology
Arterial hypertension. Arterial hypotension
Biological and medical sciences
Blood and lymphatic vessels
Blood Flow Velocity - physiology
Blood Pressure - physiology
Cardiology. Vascular system
Carotid Arteries - physiopathology
Female
Hemodynamics - physiology
Humans
Male
Medical sciences
Middle Aged
Pulse Wave Analysis
Sex Characteristics
Young Adult
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Summary:Central pressure augmentation is associated with greater backward wave amplitude and shorter transit time and is higher in women for reasons only partially elucidated. Augmentation also is affected by left ventricular function and shapes of the forward and backward waves. The goal of this study was to examine the relative contributions of forward and backward wave morphology to central pressure augmentation in men and women. From noninvasive measurements of central pressure and flow in 7437 participants (4036 women) aged from 19 to 90 years (mean age, 51 years), we calculated several variablesaugmentation index, backward wave arrival time, reflection factor, forward wave amplitude, forward wave peak width, and slope of the backward wave upstroke. Linear regression models for augmentation index, adjusted for height and heart rate, demonstrated nonlinear relations with age (ageB=4.6±0.1%; P
ISSN:0194-911X
1524-4563
DOI:10.1161/HYPERTENSIONAHA.114.03371