Deviation from optimal vascular caliber control at middle cerebral artery bifurcations harboring aneurysms

Abstract Cerebral aneurysms form preferentially at arterial bifurcations. The vascular optimality principle (VOP) decrees that minimal energy loss across bifurcations requires optimal caliber control between radii of parent ( r0 ) and daughter branches ( r1 and r2 ): r0n = r1n + r2n , with n approxi...

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Bibliographic Details
Published in:Journal of biomechanics 2014-10, Vol.47 (13), p.3318-3324
Main Authors: Baharoglu, Merih I, Lauric, Alexandra, Wu, Chengyuan, Hippelheuser, James, Malek, Adel M
Format: Article
Language:English
Subjects:
Adult
Aged
Aged, 80 and over
Aneurysms
Arteries
Bifurcation morphology
Bifurcations
Biomechanical Phenomena
Cerebral Angiography
Constants
Deviation
Endothelium
Female
Filtering
Humans
Hypotheses
Intracranial aneurysm
Intracranial Aneurysm - diagnostic imaging
Intracranial Aneurysm - pathology
Intracranial Aneurysm - physiopathology
Male
Mechanical Phenomena
Middle Aged
Middle cerebral artery
Middle Cerebral Artery - diagnostic imaging
Middle Cerebral Artery - pathology
Middle Cerebral Artery - physiopathology
Morphology
Optimal caliber control
Optimization
Parents
Patients
Physical Medicine and Rehabilitation
Software
Stress, Mechanical
Studies
Three dimensional
Veins & arteries
Young Adult
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Summary:Abstract Cerebral aneurysms form preferentially at arterial bifurcations. The vascular optimality principle (VOP) decrees that minimal energy loss across bifurcations requires optimal caliber control between radii of parent ( r0 ) and daughter branches ( r1 and r2 ): r0n = r1n + r2n , with n approximating three. VOP entails constant wall shear stress (WSS), an endothelial phenotype regulator. We sought to determine if caliber control is maintained in aneurysmal intracranial bifurcations. Three-dimensional rotational angiographic volumes of 159 middle cerebral artery (MCA) bifurcations (62 aneurysmal) were processed using 3D gradient edge-detection filtering, enabling threshold-insensitive radius measurement. Radius ratio (RR)= r03 /( r13 + r23 ) and estimated junction exponent ( n ) were compared between aneurysmal and non-aneurysmal bifurcations using Student t-test and Wilcoxon rank-sum analysis. The results show that non-aneurysmal bifurcations display optimal caliber control with mean RR of 1.05 and median n of 2.84. In contrast, aneurysmal bifurcations had significantly lower RR (0.76, p
ISSN:0021-9290
1873-2380
DOI:10.1016/j.jbiomech.2014.08.012