Deletion of C-reactive protein ameliorates experimental cerebral malaria?

Background C-reactive protein (CRP) level correlates with parasitemia and severity of malaria, but whether this reflects causality remains unknown. Methods Using CRP-transgenic and CRP-deficient mice we compared the onset and severity of experimental cerebral malaria (ECM) induced by Plasmodium berg...

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Bibliographic Details
Published in:Transactions of the Royal Society of Tropical Medicine and Hygiene 2014-09, Vol.108 (9), p.591-593
Main Authors: Szalai, Alexander J., Barnum, Scott R., Ramos, Theresa N.
Format: Article
Language:English
Subjects:
Animals
Biological and medical sciences
C-Reactive Protein - deficiency
C-Reactive Protein - genetics
C-Reactive Protein - metabolism
Carrier Proteins
General aspects
Human protozoal diseases
Infectious diseases
Malaria
Malaria, Cerebral - immunology
Malaria, Cerebral - parasitology
Malaria, Cerebral - physiopathology
Medical sciences
Mice
Mice, Inbred C57BL
Parasitic diseases
Plasmodium berghei - immunology
Plasmodium berghei - isolation & purification
Protozoal diseases
Sequence Deletion
Severity of Illness Index
Up-Regulation
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Summary:Background C-reactive protein (CRP) level correlates with parasitemia and severity of malaria, but whether this reflects causality remains unknown. Methods Using CRP-transgenic and CRP-deficient mice we compared the onset and severity of experimental cerebral malaria (ECM) induced by Plasmodium berghei ANKA (PbA). Results CRP-deficient mice were most resistant to ECM. Conclusions CRP might contribute to the development of cerebral malaria, rather than protect against it.
ISSN:0035-9203
1878-3503
DOI:10.1093/trstmh/tru098