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Deletion of C-reactive protein ameliorates experimental cerebral malaria?
Background C-reactive protein (CRP) level correlates with parasitemia and severity of malaria, but whether this reflects causality remains unknown. Methods Using CRP-transgenic and CRP-deficient mice we compared the onset and severity of experimental cerebral malaria (ECM) induced by Plasmodium berg...
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| Published in: | Transactions of the Royal Society of Tropical Medicine and Hygiene 2014-09, Vol.108 (9), p.591-593 |
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| Main Authors: | , , |
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| Language: | English |
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| cited_by | cdi_FETCH-LOGICAL-c450t-cc337fc34bddb11c6eb269f089d00d585f8c937b93aca9db54aa69e706e03ef03 |
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| cites | cdi_FETCH-LOGICAL-c450t-cc337fc34bddb11c6eb269f089d00d585f8c937b93aca9db54aa69e706e03ef03 |
| container_end_page | 593 |
| container_issue | 9 |
| container_start_page | 591 |
| container_title | Transactions of the Royal Society of Tropical Medicine and Hygiene |
| container_volume | 108 |
| creator | Szalai, Alexander J. Barnum, Scott R. Ramos, Theresa N. |
| description | Background
C-reactive protein (CRP) level correlates with parasitemia and severity of malaria, but whether this reflects causality remains unknown.
Methods
Using CRP-transgenic and CRP-deficient mice we compared the onset and severity of experimental cerebral malaria (ECM) induced by Plasmodium berghei ANKA (PbA).
Results
CRP-deficient mice were most resistant to ECM.
Conclusions
CRP might contribute to the development of cerebral malaria, rather than protect against it. |
| doi_str_mv | 10.1093/trstmh/tru098 |
| format | article |
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C-reactive protein (CRP) level correlates with parasitemia and severity of malaria, but whether this reflects causality remains unknown.
Methods
Using CRP-transgenic and CRP-deficient mice we compared the onset and severity of experimental cerebral malaria (ECM) induced by Plasmodium berghei ANKA (PbA).
Results
CRP-deficient mice were most resistant to ECM.
Conclusions
CRP might contribute to the development of cerebral malaria, rather than protect against it.</description><identifier>ISSN: 0035-9203</identifier><identifier>EISSN: 1878-3503</identifier><identifier>DOI: 10.1093/trstmh/tru098</identifier><identifier>PMID: 25002461</identifier><identifier>CODEN: TRSTAZ</identifier><language>eng</language><publisher>Oxford: Oxford University Press</publisher><subject>Animals ; Biological and medical sciences ; C-Reactive Protein - deficiency ; C-Reactive Protein - genetics ; C-Reactive Protein - metabolism ; Carrier Proteins ; General aspects ; Human protozoal diseases ; Infectious diseases ; Malaria ; Malaria, Cerebral - immunology ; Malaria, Cerebral - parasitology ; Malaria, Cerebral - physiopathology ; Medical sciences ; Mice ; Mice, Inbred C57BL ; Parasitic diseases ; Plasmodium berghei - immunology ; Plasmodium berghei - isolation & purification ; Protozoal diseases ; Sequence Deletion ; Severity of Illness Index ; Up-Regulation</subject><ispartof>Transactions of the Royal Society of Tropical Medicine and Hygiene, 2014-09, Vol.108 (9), p.591-593</ispartof><rights>The Author 2014. Published by Oxford University Press on behalf of Royal Society of Tropical Medicine and Hygiene. All rights reserved. For permissions, please e-mail: journals.permissions@oup.com. 2014</rights><rights>2015 INIST-CNRS</rights><rights>The Author 2014. Published by Oxford University Press on behalf of Royal Society of Tropical Medicine and Hygiene. All rights reserved. For permissions, please e-mail: journals.permissions@oup.com.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c450t-cc337fc34bddb11c6eb269f089d00d585f8c937b93aca9db54aa69e706e03ef03</citedby><cites>FETCH-LOGICAL-c450t-cc337fc34bddb11c6eb269f089d00d585f8c937b93aca9db54aa69e706e03ef03</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>230,314,780,784,885,27924,27925</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=28696840$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/25002461$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Szalai, Alexander J.</creatorcontrib><creatorcontrib>Barnum, Scott R.</creatorcontrib><creatorcontrib>Ramos, Theresa N.</creatorcontrib><title>Deletion of C-reactive protein ameliorates experimental cerebral malaria?</title><title>Transactions of the Royal Society of Tropical Medicine and Hygiene</title><addtitle>Trans R Soc Trop Med Hyg</addtitle><description>Background
C-reactive protein (CRP) level correlates with parasitemia and severity of malaria, but whether this reflects causality remains unknown.
Methods
Using CRP-transgenic and CRP-deficient mice we compared the onset and severity of experimental cerebral malaria (ECM) induced by Plasmodium berghei ANKA (PbA).
Results
CRP-deficient mice were most resistant to ECM.
Conclusions
CRP might contribute to the development of cerebral malaria, rather than protect against it.</description><subject>Animals</subject><subject>Biological and medical sciences</subject><subject>C-Reactive Protein - deficiency</subject><subject>C-Reactive Protein - genetics</subject><subject>C-Reactive Protein - metabolism</subject><subject>Carrier Proteins</subject><subject>General aspects</subject><subject>Human protozoal diseases</subject><subject>Infectious diseases</subject><subject>Malaria</subject><subject>Malaria, Cerebral - immunology</subject><subject>Malaria, Cerebral - parasitology</subject><subject>Malaria, Cerebral - physiopathology</subject><subject>Medical sciences</subject><subject>Mice</subject><subject>Mice, Inbred C57BL</subject><subject>Parasitic diseases</subject><subject>Plasmodium berghei - immunology</subject><subject>Plasmodium berghei - isolation & purification</subject><subject>Protozoal diseases</subject><subject>Sequence Deletion</subject><subject>Severity of Illness Index</subject><subject>Up-Regulation</subject><issn>0035-9203</issn><issn>1878-3503</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2014</creationdate><recordtype>article</recordtype><recordid>eNqFkL1PwzAQxS0EoqUwsqIsSCyBcxyn8QJC5VOqxAJzdHEu1ChfstMK_ntcUgpMTHfS_e69p8fYMYdzDkpc9Nb19cKPJah0h415Ok1DIUHssjGAkKGKQIzYgXNvAJHkUu2zUST9Hid8zB5vqKLetE3QlsEstIS6NysKOtv2ZJoAa6pMa7EnF9B7R9bU1PRYBZos5dYvNVZoDV4dsr0SK0dHmzlhL3e3z7OHcP50_zi7noc6ltCHWgsxLbWI86LIOdcJ5VGiSkhVAVDIVJapVmKaK4EaVZHLGDFRNIWEQFAJYsIuB91umddUaB_Hx8g6nwztR9aiyf5eGrPIXttVFnNfRbwWCAcBbVvnLJXbXw7ZutNs6DQbOvX8yW_DLf1dogdONwA6jVVpsdHG_XBpopL0y_hs4Npl94_nJ765ksk</recordid><startdate>20140901</startdate><enddate>20140901</enddate><creator>Szalai, Alexander J.</creator><creator>Barnum, Scott R.</creator><creator>Ramos, Theresa N.</creator><general>Oxford University Press</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>5PM</scope></search><sort><creationdate>20140901</creationdate><title>Deletion of C-reactive protein ameliorates experimental cerebral malaria?</title><author>Szalai, Alexander J. ; Barnum, Scott R. ; Ramos, Theresa N.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c450t-cc337fc34bddb11c6eb269f089d00d585f8c937b93aca9db54aa69e706e03ef03</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2014</creationdate><topic>Animals</topic><topic>Biological and medical sciences</topic><topic>C-Reactive Protein - deficiency</topic><topic>C-Reactive Protein - genetics</topic><topic>C-Reactive Protein - metabolism</topic><topic>Carrier Proteins</topic><topic>General aspects</topic><topic>Human protozoal diseases</topic><topic>Infectious diseases</topic><topic>Malaria</topic><topic>Malaria, Cerebral - immunology</topic><topic>Malaria, Cerebral - parasitology</topic><topic>Malaria, Cerebral - physiopathology</topic><topic>Medical sciences</topic><topic>Mice</topic><topic>Mice, Inbred C57BL</topic><topic>Parasitic diseases</topic><topic>Plasmodium berghei - immunology</topic><topic>Plasmodium berghei - isolation & purification</topic><topic>Protozoal diseases</topic><topic>Sequence Deletion</topic><topic>Severity of Illness Index</topic><topic>Up-Regulation</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Szalai, Alexander J.</creatorcontrib><creatorcontrib>Barnum, Scott R.</creatorcontrib><creatorcontrib>Ramos, Theresa N.</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Transactions of the Royal Society of Tropical Medicine and Hygiene</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Szalai, Alexander J.</au><au>Barnum, Scott R.</au><au>Ramos, Theresa N.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Deletion of C-reactive protein ameliorates experimental cerebral malaria?</atitle><jtitle>Transactions of the Royal Society of Tropical Medicine and Hygiene</jtitle><addtitle>Trans R Soc Trop Med Hyg</addtitle><date>2014-09-01</date><risdate>2014</risdate><volume>108</volume><issue>9</issue><spage>591</spage><epage>593</epage><pages>591-593</pages><issn>0035-9203</issn><eissn>1878-3503</eissn><coden>TRSTAZ</coden><abstract>Background
C-reactive protein (CRP) level correlates with parasitemia and severity of malaria, but whether this reflects causality remains unknown.
Methods
Using CRP-transgenic and CRP-deficient mice we compared the onset and severity of experimental cerebral malaria (ECM) induced by Plasmodium berghei ANKA (PbA).
Results
CRP-deficient mice were most resistant to ECM.
Conclusions
CRP might contribute to the development of cerebral malaria, rather than protect against it.</abstract><cop>Oxford</cop><pub>Oxford University Press</pub><pmid>25002461</pmid><doi>10.1093/trstmh/tru098</doi><tpages>3</tpages><oa>free_for_read</oa></addata></record> |
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| ispartof | Transactions of the Royal Society of Tropical Medicine and Hygiene, 2014-09, Vol.108 (9), p.591-593 |
| issn | 0035-9203 1878-3503 |
| language | eng |
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| source | Oxford Journals Online |
| subjects | Animals Biological and medical sciences C-Reactive Protein - deficiency C-Reactive Protein - genetics C-Reactive Protein - metabolism Carrier Proteins General aspects Human protozoal diseases Infectious diseases Malaria Malaria, Cerebral - immunology Malaria, Cerebral - parasitology Malaria, Cerebral - physiopathology Medical sciences Mice Mice, Inbred C57BL Parasitic diseases Plasmodium berghei - immunology Plasmodium berghei - isolation & purification Protozoal diseases Sequence Deletion Severity of Illness Index Up-Regulation |
| title | Deletion of C-reactive protein ameliorates experimental cerebral malaria? |
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