The relation between neutrophil-to-lymphocyte ratio and coronary chronic total occlusions

Neutrophil-to-lymphocyte ratio (NLR) is a marker of systemic inflammation that correlates with cardiac events. This study assessed the association between NLR and the presence of chronic coronary total occlusion (CTO). The study population included 225 patients, a control group (n = 75), a coronary...

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Bibliographic Details
Published in:BMC cardiovascular disorders 2014-09, Vol.14 (1), p.130-130, Article 130
Main Authors: Demir, Kenan, Avci, Ahmet, Altunkeser, Bulent Behlul, Yilmaz, Ahmet, Keles, Fikret, Ersecgin, Ahmet
Format: Article
Language:English
Subjects:
Acquisitions & mergers
Acute coronary syndromes
Age
Aged
Analysis
Angina pectoris
Area Under Curve
Atherosclerosis
Blood clots
Cardiovascular disease
Case-Control Studies
Chronic Disease
Comparative analysis
Coronary Angiography
Coronary Occlusion - blood
Coronary Occlusion - diagnostic imaging
Coronary Occlusion - immunology
Coronary vessels
Diabetes
Family medical history
Female
Humans
Hypertension
Logistic Models
Lymphocyte Count
Lymphocytes
Lymphocytes - immunology
Male
Measurement
Medical imaging
Medical research
Medicine, Experimental
Middle Aged
Mortality
Multivariate Analysis
Neutrophils - immunology
Normal distribution
Predictive Value of Tests
Prognosis
Regression analysis
Risk Factors
ROC Curve
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Summary:Neutrophil-to-lymphocyte ratio (NLR) is a marker of systemic inflammation that correlates with cardiac events. This study assessed the association between NLR and the presence of chronic coronary total occlusion (CTO). The study population included 225 patients, a control group (n = 75), a coronary artery disease group (n = 75), and a CTO group (n = 75). NLR was compared in the three groups. NLR levels were significantly higher in the CTO than in the other two groups (p < 0.001). Bivariate correlation analysis showed a positive correlation between NLR and SYNTAX Score, and multivariate logistic regression analysis found that NLR was an independent predictor of CTO. ROC analysis showed that an NLR cut-off of 2.09 could distinguish between patients with and without CTO (AUC = 0.74; 95% CI, 0.68-0.81), with a specificity of 69.3% and a sensitivity of 61%. NLR may be useful as a marker of CTO.
ISSN:1471-2261
1471-2261
DOI:10.1186/1471-2261-14-130