Study of the association of adrenomedullin and basic-fibroblast growth factors with the peripheral arterial blood flow and endothelial dysfunction biomarkers in type 2 diabetic patients with peripheral vascular insufficiency

• Published in: Journal of biomedical science 2014-10, Vol.21 (1), p.94-94, Article 94
• Main Authors: Alrouq, Fawziah A, Al-Masri, Abeer A, Al-Dokhi, Laila M, Alregaiey, Khalid A, Bayoumy, Nervana M, Zakareia, Faten A
• Format: Article
• Language: English
• Subjects: Adrenomedullin - blood; Adrenomedullin - genetics; Angiogenesis; Ankle Brachial Index; Apoptosis; Arteries - physiopathology; Biological markers; Biomarkers - blood; Blood; Blood circulation disorders; Cell adhesion & migration; Cell Adhesion Molecules - blood; Cell Adhesion Molecules - genetics; Cell growth; Diabetes; Diabetes Mellitus, Type 2 - blood; Diabetes Mellitus, Type 2 - physiopathology; Diabetes therapy; Diabetic neuropathy; Diabetic retinopathy; Diabetics; Endothelium; Endothelium, Vascular - physiopathology; Enzyme-Linked Immunosorbent Assay; Enzymes; Female; Fibroblast Growth Factor 2 - blood; Fibroblast Growth Factor 2 - genetics; Fibroblast growth factors; Heart attacks; Humans; Intercellular Adhesion Molecule-1 - blood; Intercellular Adhesion Molecule-1 - genetics; Laboratories; Medical research; Medicine, Experimental; Middle Aged; Mortality; Oxidative stress; Peripheral Vascular Diseases - blood; Peripheral Vascular Diseases - physiopathology; Proteins; Regional Blood Flow; Risk factors; Saudi Arabia; Studies; Type 2 diabetes; Vascular Cell Adhesion Molecule-1 - blood; Vascular Cell Adhesion Molecule-1 - genetics
• ISSN: 1423-0127; 1021-7770; 1423-0127
• DOI: 10.1186/s12929-014-0094-y

Progressive micro-vascular vaso-degeneration is the major factor in progression of diabetic complications. Adrenomedullin (AM) and basic-Fibroblast growth factor (b-FGF) are strongly correlated with angiogenesis in vascular diseases. This study aims to provide base line data regarding the vascular effects and correlation of AM, and b-FGF with the peripheral blood flow in diabetic patients with peripheral vascular disease (PVD), and their effect on endothelial dysfunction markers. Ninety age- and sex matched females were enrolled in the study: 30 were controls, 30 had diabetes without complications (group II) and 30 had diabetes with PVD (group III) diagnosed by ankle/ brachial index (A/BI). Plasma levels of AM, b-FGF, intercellular adhesion molecule -1 (ICAM-1) and vascular cell adhesion molecule-1 (VCAM-1) were measured by indirect enzyme immunoassay (ELISA). There was a significant increase in plasma AM, VCAM-1and ICAM-1, while a significant decrease in plasma b-FGF in diabetic patients with PVD (p