Potential therapeutic roles of tanshinone IIA in human bladder cancer cells

Tanshinone IIA (Tan-IIA), one of the major lipophilic components isolated from the root of Salviae Miltiorrhizae, has been found to exhibit anticancer activity in various cancer cells. We have demonstrated that Tan-IIA induces apoptosis in several human cancer cells through caspase- and mitochondria...

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Published in:International journal of molecular sciences 2014-09, Vol.15 (9), p.15622-15637
Main Authors: Chiu, Sheng-Chun, Huang, Sung-Ying, Chang, Shu-Fang, Chen, Shee-Ping, Chen, Chi-Cheng, Lin, Tien-Huang, Liu, Hsin-Ho, Tsai, Tsung-Hsun, Lee, Shang-Sen, Pang, Cheng-Yoong, Hsieh, Teng-Fu
Format: Article
Language:English
Subjects:
Antineoplastic Agents - pharmacology
Apoptosis
Bladder cancer
Cell Line, Tumor
Cell Movement
Cells
Cisplatin - pharmacology
Diterpenes, Abietane - pharmacology
Drug therapy
Epithelial Cells - drug effects
Epithelial Cells - metabolism
Epithelial Cells - physiology
Humans
Urinary Bladder Neoplasms - metabolism
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Summary:Tanshinone IIA (Tan-IIA), one of the major lipophilic components isolated from the root of Salviae Miltiorrhizae, has been found to exhibit anticancer activity in various cancer cells. We have demonstrated that Tan-IIA induces apoptosis in several human cancer cells through caspase- and mitochondria-dependent pathways. Here we explored the anticancer effect of Tan-IIA in human bladder cancer cell lines. Our results showed that Tan-IIA caused bladder cancer cell death in a time- and dose-dependent manner. Tan-IIA induced apoptosis through the mitochondria-dependent pathway in these bladder cancer cells. Tan-IIA also suppressed the migration of bladder cancer cells as revealed by the wound healing and transwell assays. Finally, combination therapy of Tan-IIA with a lower dose of cisplatin successfully killed bladder cancer cells, suggesting that Tan-IIA can serve as a potential anti-cancer agent in bladder cancer.
ISSN:1422-0067
1661-6596
1422-0067
DOI:10.3390/ijms150915622