Effect of lateralized temporal lobe epilepsy on the default mode network

Abstract The default mode network (DMN) is composed of cerebral regions involved in conscious, resting state cognition. The hippocampus is an essential component of this network. Here, the DMN in TLE is compared to control subjects to better understand its involvement in TLE. We performed resting st...

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Bibliographic Details
Published in:Epilepsy & behavior 2012-11, Vol.25 (3), p.350-357
Main Authors: Haneef, Zulfi, Lenartowicz, Agatha, Yeh, Hsiang J, Engel, Jerome, Stern, John M
Format: Article
Language:English
Subjects:
Adult
Brain Mapping
Cognitive ability
Cortex
Cortex (parietal)
Default mode network (DMN)
Epilepsy
Epilepsy psychopathology
Epilepsy, Temporal Lobe - pathology
Epilepsy, Temporal Lobe - physiopathology
Epileptic networks
Female
fMRI
Functional connectivity
Functional Laterality - physiology
Hemispheric laterality
Hippocampus
Humans
Image Processing, Computer-Assisted
Magnetic Resonance Imaging
Male
Memory
Middle Aged
Models, Neurological
Neural Pathways - pathology
Neurology
Temporal lobe
Temporal Lobe Epilepsy (TLE)
Young Adult
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Summary:Abstract The default mode network (DMN) is composed of cerebral regions involved in conscious, resting state cognition. The hippocampus is an essential component of this network. Here, the DMN in TLE is compared to control subjects to better understand its involvement in TLE. We performed resting state connectivity analysis using regions of interest (ROIs) in the retrosplenium/precuneus (Rsp/PCUN) and the ventro-medial pre-frontal cortex (vmPFC) in 36 subjects (11 with right TLE, 12 with left TLE, 13 controls) to delineate the posterior and anterior DMN regions respectively. We found reduced connectivity of the posterior to the anterior DMN in patients with both right and left TLE. However, the posterior and anterior networks were found to be individually preserved. Lateralization of TLE affects the DMN with left TLE demonstrating more extensive networks. These DMN changes may be relevant to altered cognition and memory in TLE and may be relevant to right vs. left TLE differences in cognitive involvement.
ISSN:1525-5050
1525-5069
DOI:10.1016/j.yebeh.2012.07.019