Hepatocyte Growth Factor Levels in the Saliva and Gingival Crevicular Fluid in Smokers with Periodontitis

Hepatocyte growth factor (HGF) production by oral fibroblasts is enhanced by various molecules that are induced during inflammatory conditions including periodontitis. HGF plays an important role in the progression of periodontitis, by stimulating intense growth of epithelial cells and preventing re...

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Bibliographic Details
Published in:Disease markers 2014-01, Vol.2014 (2014), p.1-6
Main Authors: al-Kharif, Abd al-Aziz Abd Allah, Krishnan, Anitha P., AlMoharib, Hani S., Mokeem, Sameer A., Preethanath, R. S., Vellappally, Sajith, Anil, Sukumaran, Chalisserry, Elna P.
Format: Article
Language:English
Subjects:
Adult
Case-Control Studies
Development and progression
Gingival Crevicular Fluid - metabolism
Gingivitis - diagnosis
Gingivitis - metabolism
Growth factors
Hepatocyte Growth Factor - metabolism
Humans
Liver cells
Middle Aged
Periodontitis
Physiological aspects
Saliva - metabolism
Smokers
Smoking - adverse effects
Smoking - metabolism
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Summary:Hepatocyte growth factor (HGF) production by oral fibroblasts is enhanced by various molecules that are induced during inflammatory conditions including periodontitis. HGF plays an important role in the progression of periodontitis, by stimulating intense growth of epithelial cells and preventing regeneration of connective tissue attachments. Smokers have a greater risk factor in the pathogenesis and progression of periodontal disease. The objective of the study was to estimate the level of HGF in saliva and gingival crevicular fluid (GCF) in smokers with periodontitis and to compare these levels with that of nonsmokers with periodontitis and healthy controls. The HGF levels were found to be significantly high in the saliva and GCF of smokers with periodontitis compared to both never-smokers with periodontitis and the healthy control group. The elevated levels of HGF in the saliva and GCF in the study population could explain the intrinsic mechanism triggering the severity of the periodontitis in smokers. Further studies are necessary to validate the current observations and to establish a sensitive marker to predict periodontal disease activity.
ISSN:0278-0240
1875-8630
DOI:10.1155/2014/146974