A SNP in the 5' flanking region of the myostatin-1b gene is associated with harvest traits in Atlantic salmon (Salmo salar)

Myostatin (MSTN) belongs to the transforming growth factor-β superfamily and is a potent negative regulator of skeletal muscle development and growth in mammals. Most teleost fish possess two MSTN paralogues. However, as a consequence of a recent whole genome-duplication event, salmonids have four:...

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Bibliographic Details
Published in:BMC genetics 2013-11, Vol.14 (1), p.112-112, Article 112
Main Authors: Peñaloza, Carolina, Hamilton, Alastair, Guy, Derrick R, Bishop, Stephen C, Houston, Ross D
Format: Article
Language:English
Subjects:
5' Flanking Region - genetics
Alleles
Analysis
Animals
Aquaculture industry
Atlantic salmon
Body Weight - genetics
Fish
Genes
Genetic aspects
Genotype
Haplotypes
Marine
Mutation
Myostatin
Myostatin - genetics
Phenotype
Physiological aspects
Polymorphism, Single Nucleotide - genetics
Salmo salar
Salmo salar - genetics
Salmon
Single nucleotide polymorphisms
Teleostei
Zebrafish
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Summary:Myostatin (MSTN) belongs to the transforming growth factor-β superfamily and is a potent negative regulator of skeletal muscle development and growth in mammals. Most teleost fish possess two MSTN paralogues. However, as a consequence of a recent whole genome-duplication event, salmonids have four: MSTN-1 (-1a and -1b) and MSTN-2 (-2a and -2b). Evidence suggests that teleost MSTN plays a role in the regulation of muscle growth. In the current study, the MSTN-1b gene was re-sequenced and screened for SNP markers in a commercial population of Atlantic salmon. After genotyping 4,800 progeny for the discovered SNPs, we investigated their association with eight harvest traits - four body-weight traits, two ratios of weight traits, flesh colour and fat percentage - using a mixed model association analysis. Three novel SNPs were discovered in the MSTN-1b gene of Atlantic salmon. One of the SNPs, located within the 5' flanking region (g.1086C > T), had a significant association with harvest traits (p  T had a significant association with all body-weight traits under study. Although the SNP explains a small percentage of the variance, our results indicate that a variation in the 5' flanking region of the myostatin gene is associated with the genetic regulation of growth in Atlantic salmon.
ISSN:1471-2156
1471-2156
DOI:10.1186/1471-2156-14-112