Hepcidin levels in diabetes mellitus and polycystic ovary syndrome

Aim Increased body iron is associated with insulin resistance. Hepcidin is the key hormone that negatively regulates iron homeostasis. We hypothesized that individuals with insulin resistance have inadequate hepcidin levels for their iron load. Methods Serum concentrations of the active form of hepc...

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Bibliographic Details
Published in:Diabetic medicine 2013-12, Vol.30 (12), p.1495-1499
Main Authors: Sam, A. H., Busbridge, M., Amin, A., Webber, L., White, D., Franks, S., Martin, N. M., Sleeth, M., Ismail, N. A., Daud, N. Mat, Papamargaritis, D., Le Roux, C. W., Chapman, R. S., Frost, G., Bloom, S. R., Murphy, K. G.
Format: Article
Language:English
Subjects:
Adult
Biological and medical sciences
Blood Glucose - metabolism
Diabetes
Diabetes Mellitus, Type 1 - blood
Diabetes Mellitus, Type 2 - blood
Diabetes. Impaired glucose tolerance
Endocrine pancreas. Apud cells (diseases)
Endocrinopathies
Etiopathogenesis. Screening. Investigations. Target tissue resistance
Feeding. Feeding behavior
Female
Ferritins - blood
Ferritins - deficiency
Fundamental and applied biological sciences. Psychology
Hepcidins - blood
Hepcidins - deficiency
Homeostasis
Humans
Insulin Resistance
Intercellular Signaling Peptides and Proteins - metabolism
Male
Medical sciences
Middle Aged
Polycystic Ovary Syndrome - blood
Vertebrates: anatomy and physiology, studies on body, several organs or systems
Vertebrates: endocrinology
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Summary:Aim Increased body iron is associated with insulin resistance. Hepcidin is the key hormone that negatively regulates iron homeostasis. We hypothesized that individuals with insulin resistance have inadequate hepcidin levels for their iron load. Methods Serum concentrations of the active form of hepcidin (hepcidin‐25) and hepcidin:ferritin ratio were evaluated in participants with Type 2 diabetes (n = 33, control subjects matched for age, gender and BMI, n = 33) and participants with polycystic ovary syndrome (n = 27, control subjects matched for age and BMI, n = 16). To investigate whether any changes observed were associated with insulin resistance rather than insulin deficiency or hyperglycaemia per se, the same measurements were made in participants with Type 1 diabetes (n = 28, control subjects matched for age, gender and BMI, n = 30). Finally, the relationship between homeostasis model assessment of insulin resistance and serum hepcidin:ferritin ratio was explored in overweight or obese participants without diabetes (n = 16). Results Participants with Type 2 diabetes had significantly lower hepcidin and hepcidin:ferritin ratio than control subjects (P 
ISSN:0742-3071
1464-5491
DOI:10.1111/dme.12262