Bone mineral density and atherosclerosis: The Multi-Ethnic Study of Atherosclerosis, Abdominal Aortic Calcium Study

Abstract Context Molecular and cell biology studies have demonstrated an association between bone and arterial wall disease, but the significance of a population-level association is less clear and potentially confounded by inability to account for shared risk factors. Objective To test population-l...

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Bibliographic Details
Published in:Atherosclerosis 2010-03, Vol.209 (1), p.283-289
Main Authors: Hyder, Joseph A, Allison, Matthew A, Barrett-Connor, Elizabeth, Detrano, Robert, Wong, Nathan D, Sirlin, Claude, Gapstur, Susan M, Ouyang, Pamela, Carr, J. Jeffrey, Criqui, Michael H
Format: Article
Language:English
Subjects:
Age
Aorta, Abdominal - diagnostic imaging
Aorta, Abdominal - physiopathology
Atherosclerosis
Atherosclerosis (general aspects, experimental research)
Atherosclerosis - diagnostic imaging
Atherosclerosis - ethnology
Atherosclerosis - physiopathology
Biological and medical sciences
Blood and lymphatic vessels
Bone
Bone Density
Calcium - metabolism
Cardiology. Vascular system
Cardiovascular
Carotid Arteries - diagnostic imaging
Carotid Arteries - physiopathology
Diseases of the aorta
Female
Hormones
Humans
Inflammation
Lipids
Lumbar Vertebrae - diagnostic imaging
Lumbar Vertebrae - physiopathology
Male
Medical sciences
Middle Aged
Radiography
Sex Factors
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Summary:Abstract Context Molecular and cell biology studies have demonstrated an association between bone and arterial wall disease, but the significance of a population-level association is less clear and potentially confounded by inability to account for shared risk factors. Objective To test population-level associations between atherosclerosis types and bone integrity. Main outcome measures Volumetric trabecular lumbar bone mineral density (vBMD), ankle-brachial index (ABI), intima-media thickness (IMT) of the common carotid (CCA-IMT) and internal carotid (ICA-IMT) arteries, and carotid plaque echogenicity. Design, setting and participants A random subset of participants from the Multi-Ethnic Study of Atherosclerosis (MESA) assessed between 2002 and 2005. Results 904 post-menopausal female (62.4 years; 62% non-white; 12% ABI 1 mm; 33% ICA-IMT >1 mm) and 929 male (61.4 years; 58% non-white; 6% ABI 1 mm; 40% ICA-IMT >1 mm) were included. In serial, sex-specific regression models adjusting for age, ethnicity, body mass index, dyslipidemia, hypertension, smoking, alcohol consumption, diabetes, homocysteine, interleukin-6, sex hormones, and renal function, lower vBMD was associated with lower ABI in men ( p for trend
ISSN:0021-9150
1879-1484
DOI:10.1016/j.atherosclerosis.2009.09.011