Long-range ordered vorticity patterns in living tissue induced by cell division

In healthy blood vessels with a laminar blood flow, the endothelial cell division rate is low, only sufficient to replace apoptotic cells. The division rate significantly increases during embryonic development and under halted or turbulent flow. Cells in barrier tissue are connected and their motili...

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Bibliographic Details
Published in:Nature communications 2014-12, Vol.5 (1), p.5720-5720, Article 5720
Main Authors: Rossen, Ninna S., Tarp, Jens M., Mathiesen, Joachim, Jensen, Mogens H., Oddershede, Lene B.
Format: Article
Language:English
Subjects:
14/63
639/766/189
639/766/747
Biophysics
Blood Flow Velocity
Cell Division
Cytoplasm - metabolism
Endothelial Cells - cytology
Fourier Analysis
Hemodynamics
Human Umbilical Vein Endothelial Cells
Humanities and Social Sciences
Humans
Hydrodynamics
Microscopy, Phase-Contrast
Models, Cardiovascular
Models, Theoretical
multidisciplinary
Science
Science (multidisciplinary)
Stress, Mechanical
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Summary:In healthy blood vessels with a laminar blood flow, the endothelial cell division rate is low, only sufficient to replace apoptotic cells. The division rate significantly increases during embryonic development and under halted or turbulent flow. Cells in barrier tissue are connected and their motility is highly correlated. Here we investigate the long-range dynamics induced by cell division in an endothelial monolayer under non-flow conditions, mimicking the conditions during vessel formation or around blood clots. Cell divisions induce long-range, well-ordered vortex patterns extending several cell diameters away from the division site, in spite of the system’s low Reynolds number. Our experimental results are reproduced by a hydrodynamic continuum model simulating division as a local pressure increase corresponding to a local tension decrease. Such long-range physical communication may be crucial for embryonic development and for healing tissue, for instance around blood clots. Endothelial cell division is highly sensitive to fluid conditions and essential for blood vessel healing. Here Rossen et al. demonstrate how cell division triggers the emergence of long-range votex patterns in endothelial tissue under conditions that mimic blood vessel formation and blood clots.
ISSN:2041-1723
2041-1723
DOI:10.1038/ncomms6720