A nairovirus isolated from African bats causes haemorrhagic gastroenteritis and severe hepatic disease in mice

Bats can carry important zoonotic pathogens. Here we use a combination of next-generation sequencing and classical virus isolation methods to identify novel nairoviruses from bats captured from a cave in Zambia. This nairovirus infection is highly prevalent among giant leaf-nosed bats, Hipposideros...

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Bibliographic Details
Published in:Nature communications 2014-12, Vol.5 (1), p.5651-5651, Article 5651
Main Authors: Ishii, Akihiro, Ueno, Keisuke, Orba, Yasuko, Sasaki, Michihito, Moonga, Ladslav, Hang’ombe, Bernard M., Mweene, Aaron S., Umemura, Takashi, Ito, Kimihito, Hall, William W., Sawa, Hirofumi
Format: Article
Language:English
Subjects:
692/420
692/699/1503/1501
692/699/1503/1607
692/699/255/2514
Animals
Base Sequence
Bats
Chiroptera - virology
Disease Models, Animal
Gastroenteritis - virology
Gastrointestinal Hemorrhage - virology
Hemorrhagic Fever, Crimean - virology
Hepatitis, Viral, Animal - virology
Humanities and Social Sciences
Mice
Molecular Sequence Data
multidisciplinary
Nairovirus - genetics
Nairovirus - isolation & purification
RNA, Viral - analysis
Science
Science (multidisciplinary)
Veterinary colleges
Viruses
Zoonoses
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Summary:Bats can carry important zoonotic pathogens. Here we use a combination of next-generation sequencing and classical virus isolation methods to identify novel nairoviruses from bats captured from a cave in Zambia. This nairovirus infection is highly prevalent among giant leaf-nosed bats, Hipposideros gigas (detected in samples from 16 individuals out of 38). Whole-genome analysis of three viral isolates (11SB17, 11SB19 and 11SB23) reveals a typical bunyavirus tri-segmented genome. The strains form a single phylogenetic clade that is divergent from other known nairoviruses, and are hereafter designated as Leopards Hill virus (LPHV). When i.p. injected into mice, the 11SB17 strain causes only slight body weight loss, whereas 11SB23 produces acute and lethal disease closely resembling that observed with Crimean–Congo Haemorrhagic Fever virus in humans. We believe that our LPHV mouse model will be useful for research on the pathogenesis of nairoviral haemorrhagic disease. Bats carry viruses that can cause disease in other animals and in humans. Here, Ishii et al. identify new nairoviruses from African bats and show that some of them can produce a severe haemorrhagic disease in laboratory mice that is similar to Crimean–Congo haemorrhagic fever in humans.
ISSN:2041-1723
2041-1723
DOI:10.1038/ncomms6651