Reduced Handgrip Strength as a Marker of Frailty Predicts Clinical Outcomes in Patients With Heart Failure Undergoing Ventricular Assist Device Placement

Abstract Background Heart failure (HF) is associated with the derangement of muscle structure and metabolism, contributing to exercise intolerance, frailty, and mortality. Reduced handgrip strength is associated with increased patient frailty and higher morbidity and mortality. We evaluated handgrip...

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Bibliographic Details
Published in:Journal of cardiac failure 2014-05, Vol.20 (5), p.310-315
Main Authors: Chung, Christine J., MD, Wu, Christina, MS, Jones, Meaghan, BS, Kato, Tomoko S., MD, Dam, Tien T., MD, Givens, Raymond C., MD, PhD, Templeton, Danielle L., PhD, Maurer, Mathew S., MD, Naka, Yoshifumi, MD, PhD, Takayama, Hiroo, MD, Mancini, Donna M., MD, Schulze, P. Christian, MD, PhD
Format: Article
Language:English
Subjects:
Cardiovascular
Cohort Studies
Female
Hand Strength - physiology
handgrip strength
Heart failure
Heart Failure - diagnosis
Heart Failure - mortality
Heart Failure - therapy
Heart-Assist Devices - trends
Humans
Male
Middle Aged
Postoperative Complications - diagnosis
Postoperative Complications - mortality
Predictive Value of Tests
skeletal muscle
Survival Rate - trends
Treatment Outcome
ventricular assist device
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Summary:Abstract Background Heart failure (HF) is associated with the derangement of muscle structure and metabolism, contributing to exercise intolerance, frailty, and mortality. Reduced handgrip strength is associated with increased patient frailty and higher morbidity and mortality. We evaluated handgrip strength as a marker of muscle function and frailty for prediction of clinical outcomes after ventricular assist device (VAD) implantation in patients with advanced HF. Methods and Results Handgrip strength was measured in 72 patients with advanced HF before VAD implantation (2.3 ± 4.9 days pre-VAD). We analyzed dynamics in handgrip strength, laboratory values, postoperative complications, and mortality. Handgrip strength correlated with serum albumin levels ( r  = 0.334, P  = .004). Compared with baseline, handgrip strength increased post-VAD implantation by 18.2 ± 5.6% at 3 months (n = 29) and 45.5 ± 23.9% at 6 months (n = 27). Patients with a handgrip strength
ISSN:1071-9164
1532-8414
DOI:10.1016/j.cardfail.2014.02.008