Mammalian ER mannosidase I resides in quality control vesicles, where it encounters its glycoprotein substrates

Endoplasmic reticulum α1,2 mannosidase I (ERManI), a central component of ER quality control and ER-associated degradation (ERAD), acts as a timer enzyme, modifying N-linked sugar chains of glycoproteins with time. This process halts glycoprotein folding attempts when necessary and targets terminall...

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Bibliographic Details
Published in:Molecular biology of the cell 2015-01, Vol.26 (2), p.172-184
Main Authors: Benyair, Ron, Ogen-Shtern, Navit, Mazkereth, Niv, Shai, Ben, Ehrlich, Marcelo, Lederkremer, Gerardo Z.
Format: Article
Language:English
Subjects:
Animals
Autophagy
Cytoplasmic Vesicles - metabolism
Endoplasmic Reticulum - enzymology
Endoplasmic Reticulum Stress
Endoplasmic Reticulum-Associated Degradation
Fluorescence Resonance Energy Transfer
Glycoproteins - metabolism
HEK293 Cells
HeLa Cells
Humans
Immunoblotting
Luminescent Proteins - genetics
Luminescent Proteins - metabolism
Mannosidases - genetics
Mannosidases - metabolism
Mice
Microscopy, Confocal
Microtubule-Associated Proteins - genetics
Microtubule-Associated Proteins - metabolism
Microtubules - metabolism
NIH 3T3 Cells
Substrate Specificity
Time-Lapse Imaging - methods
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