Brain pathology contributes to simultaneous change in physical frailty and cognition in old age

First, we tested the hypothesis that the rate of change of physical frailty and cognitive function in older adults are correlated. Next, we examined if their rates of change are associated with the same brain pathologies. About 2,167 older adults participating in the Religious Orders Study and the R...

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Bibliographic Details
Published in:The journals of gerontology. Series A, Biological sciences and medical sciences Biological sciences and medical sciences, 2014-12, Vol.69 (12), p.1536-1544
Main Authors: Buchman, Aron S, Yu, Lei, Wilson, Robert S, Boyle, Patricia A, Schneider, Julie A, Bennett, David A
Format: Article
Language:English
Subjects:
Aged
Aged, 80 and over
Aging - physiology
Brain - pathology
Cognition & reasoning
Cognition - physiology
Cognition Disorders - diagnosis
Cognition Disorders - physiopathology
Cognition Disorders - psychology
Correlation analysis
Demographics
Disease Progression
Female
Follow-Up Studies
Frail Elderly
Frailty
Humans
Male
Motor Activity - physiology
Neuropathology
Neuropsychological Tests
Older people
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Summary:First, we tested the hypothesis that the rate of change of physical frailty and cognitive function in older adults are correlated. Next, we examined if their rates of change are associated with the same brain pathologies. About 2,167 older adults participating in the Religious Orders Study and the Rush Memory and Aging Project had annual clinical evaluations. Bivariate random coefficient models were used to estimate simultaneously the rates of change in both frailty and cognition, and the correlation of change was characterized by a joint distribution of the random effects. Then, we examined whether postmortem indices from deceased were associated with the rate of change of frailty and cognition. During an average follow-up of 6 years, frailty worsened by 0.09 unit/y and cognition declined by 0.08 unit/y. Most individuals showed worsening frailty and cognition (82.8%); 17% showed progressive frailty alone and
ISSN:1079-5006
1758-535X
DOI:10.1093/gerona/glu117