Early visual cortex reflects initiation and maintenance of task set

• Published in: NeuroImage (Orlando, Fla.) Fla.), 2015-02, Vol.107, p.277-288
• Main Authors: Elkhetali, Abdurahman S, Vaden, Ryan J, Pool, Sean M, Visscher, Kristina M
• Format: Article
• Language: English
• Subjects: Acoustic Stimulation; Adult; Alzheimer's disease; Attention; Attention - physiology; Auditory Perception - physiology; Behavior; Brain mapping; Brain research; Cognition - physiology; Cues; Experiments; Female; Functional magnetic resonance imaging; Humans; Information processing; Magnetic Resonance Imaging; Male; Neuroimaging; NMR; Nuclear magnetic resonance; Photic Stimulation; Psychomotor Performance - physiology; Retina - physiology; Roles; Sensory integration; Sensory Thresholds; Visual cortex; Visual Cortex - physiology; Visual perception; Visual Perception - physiology; Visual stimuli; Visual task performance; Young Adult
• ISSN: 1053-8119; 1095-9572
• DOI: 10.1016/j.neuroimage.2014.11.061

The human brain is able to process information flexibly, depending on a person's task. The mechanisms underlying this ability to initiate and maintain a task set are not well understood, but they are important for understanding the flexibility of human behavior and developing therapies for disorders involving attention. Here we investigate the differential roles of early visual cortical areas in initiating and maintaining a task set. Using functional Magnetic Resonance Imaging (fMRI), we characterized three different components of task set-related, but trial-independent activity in retinotopically mapped areas of early visual cortex, while human participants performed attention demanding visual or auditory tasks. These trial-independent effects reflected: (1) maintenance of attention over a long duration, (2) orienting to a cue, and (3) initiation of a task set. Participants performed tasks that differed in the modality of stimulus to be attended (auditory or visual) and in whether there was a simultaneous distractor (auditory only, visual only, or simultaneous auditory and visual). We found that patterns of trial-independent activity in early visual areas (V1, V2, V3, hV4) depend on attended modality, but not on stimuli. Further, different early visual areas play distinct roles in the initiation of a task set. In addition, activity associated with maintaining a task set tracks with a participant's behavior. These results show that trial-independent activity in early visual cortex reflects initiation and maintenance of a person's task set.