Long-term effects of tetanus toxoid inoculation on the demography and life expectancy of the Cayo Santiago rhesus macaques

• Published in: American journal of primatology 2015-02, Vol.77 (2), p.211-221
• Main Authors: Kessler, Matthew J., Hernández Pacheco, Raisa, Rawlins, Richard G., Ruiz-Lambrides, Angelina, Delgado, Diana L., Sabat, Alberto M.
• Format: Article
• Language: English
• Subjects: Age distribution; Animals; Demography; Distribution; Female; Life Expectancy; life table; life table response experiment; Life Tables; Macaca mulatta; Macaca mulatta - immunology; Male; matrix projection model; Monkey Diseases - immunology; Monkey Diseases - prevention & control; Mortality; Population; Puerto Rico; Reproduction - physiology; Retrospective Studies; survivorship; Tetanus - prevention & control; Tetanus - veterinary; Tetanus Toxoid - immunology; Time; Vaccination
• ISSN: 0275-2565; 1098-2345
• DOI: 10.1002/ajp.22323

Tetanus was a major cause of mortality in the free‐ranging population of rhesus monkeys on Cayo Santiago prior to 1985 when the entire colony was given its first dose of tetanus toxoid. The immediate reduction in mortality that followed tetanus toxoid inoculation (TTI) has been documented, but the long‐term demographic effects of eliminating tetanus infections have not. This study uses the Cayo Santiago demographic database to construct comparative life tables 12 years before, and 12 years after, TTI. Life tables and matrix projection models are used to test for differences in: (i) survival among all individuals as well as among social groups, (ii) long‐term fitness of the population, (iii) age distribution, (iv) reproductive value, and (v) life expectancy. A retrospective life table response experiment (LTRE) was performed to determine which life cycle transition contributed most to observed changes in long‐term fitness of the population post‐TTI. Elimination of clinical tetanus infections through mass inoculation improved the health and well‐being of the monkeys. It also profoundly affected the population by increasing survivorship and long‐term fitness, decreasing the differences in survival rates among social groups, shifting the population's age distribution towards older individuals, and increasing reproductive value and life expectancy. These findings are significant because they demonstrate the long‐term effects of eradicating a major cause of mortality at a single point in time on survival, reproduction, and overall demography of a naturalistic population of primates. Am. J. Primatol. 77:211–221, 2015. © 2014 Wiley Periodicals, Inc.