Elevated expression levels of androgen receptors and matrix metalloproteinase-2 and -9 in 30 cases of hepatocellular carcinoma compared with adjacent tissues as predictors of cancer invasion and staging

The aim of the present study was to investigate the potential roles of the androgen receptor (AR) and matrix metalloproteinase (MMP)-2 and MMP-9 in hepatocellular carcinoma (HCC) tissues and whether their expression could be used as a predictor of the invasion and stage of cancer. The expression lev...

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Bibliographic Details
Published in:Experimental and therapeutic medicine 2015-03, Vol.9 (3), p.905-908
Main Authors: ZHANG, YAN, SHEN, YUCHENG, CAO, BIN, YAN, AITING, JI, HAOMING
Format: Article
Language:English
Subjects:
Age
Alcohol
androgen receptor
Androgens
Cancer therapies
Care and treatment
Development and progression
Enzymes
Extracellular matrix
Females
Genetic aspects
Hepatitis
hepatocellular carcinoma
Hepatoma
Immunohistochemistry
Liver cancer
Males
matrix metalloproteinase-2
matrix metalloproteinase-9
Metastasis
Mortality
Physiological aspects
Studies
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Summary:The aim of the present study was to investigate the potential roles of the androgen receptor (AR) and matrix metalloproteinase (MMP)-2 and MMP-9 in hepatocellular carcinoma (HCC) tissues and whether their expression could be used as a predictor of the invasion and stage of cancer. The expression levels of AR, MMP-2 and MMP-9 in HCC tissues and tissues adjacent to the tumor were measured by immunohistochemical staining assay. The expression rates of AR, MMP-2 and MMP-9 in the HCC tissue were 76.67, 73.33 and 76.67%, respectively, all of which were significantly higher than those in the tissues adjacent to the tumor. The expression of these proteins represents the local invasion and stage. AR, MMP-2 and MMP-9 expression levels in HCC tissues have the potential to be employed as predictors of the progression of local cancer invasion and the tumor stage.
ISSN:1792-0981
1792-1015
DOI:10.3892/etm.2014.2150