Invasive adenoma and pituitary carcinoma: a SEER database analysis

• Published in: Neurosurgical review 2014-04, Vol.37 (2), p.279-286
• Main Authors: Hansen, Tara M., Batra, Sachin, Lim, Michael, Gallia, Gary L., Burger, Peter C., Salvatori, Roberto, Wand, Gary, Quinones-Hinojosa, Alfredo, Kleinberg, Lawrence, Redmond, Kristin J.
• Format: Article
• Language: English
• Subjects: Adenoma - surgery; Adult; Age Distribution; Aged; Aged, 80 and over; Female; Humans; Male; Medicine; Medicine & Public Health; Middle Aged; Neoplasm Invasiveness; Neurosurgery; Original Article; Pituitary Neoplasms - pathology; Pituitary Neoplasms - surgery; Prognosis; Treatment Outcome
• ISSN: 0344-5607; 1437-2320
• DOI: 10.1007/s10143-014-0525-y

Invasive pituitary adenomas and pituitary carcinomas are clinically indistinguishable until identification of metastases. Optimal management and survival outcomes for both are not clearly defined. The purpose of this study is to use the Surveillance, Epidemiology, and End Results (SEER) database to report patterns of care and compare survival outcomes in a large series of patients with invasive adenomas or pituitary carcinomas. One hundred seventeen patients diagnosed between 1973 and 2008 with pituitary adenomas/adenocarcinomas were included. Eighty-three invasive adenomas and seven pituitary carcinomas were analyzed for survival outcomes. Analyzed prognostic factors included age, sex, race, histology, tumor extent, and treatment. A significant decrease in survival was observed among carcinomas compared to invasive adenomas at 1, 2, and 5 years ( p  = 0.047, 0.001, and 0.009). Only non-white race, male gender, and age ≥65 were significant negative prognostic factors for invasive adenomas ( p  = 0.013, 0.033, and