Nonhuman primate infants have an impaired respiratory but not systemic IgG antibody response following influenza virus infection

Abstract Respiratory infection of young infants results in increased morbidity and mortality compared to infection of adults. In spite of the significance of this health issue, our understanding of the immune response elicited in infants especially in the respiratory tract is highly limited. We deve...

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Bibliographic Details
Published in:Virology (New York, N.Y.) N.Y.), 2015-02, Vol.476, p.124-133
Main Authors: Holbrook, Beth C, Hayward, Sarah L, Blevins, Lance K, Kock, Nancy, Aycock, Tyler, Parks, Griffith D, Alexander-Miller, Martha A
Format: Article
Language:English
Subjects:
Animals
Animals, Newborn
Antibodies, Viral - immunology
Antibody
Antibody Formation
Bronchus associated lymphoid tissue
Chlorocebus aethiops
Disease Models, Animal
Female
Humans
Immunoglobulin G - immunology
Infant
Infant, Newborn
Infant, Newborn, Diseases - immunology
Infant, Newborn, Diseases - virology
Infectious Disease
Influenza A virus - physiology
Influenza virus
Influenza, Human - immunology
Influenza, Human - virology
Lung pathology
Male
Neonatal immunity
Respiratory infection
Respiratory Tract Infections - immunology
Respiratory Tract Infections - virology
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Summary:Abstract Respiratory infection of young infants results in increased morbidity and mortality compared to infection of adults. In spite of the significance of this health issue, our understanding of the immune response elicited in infants especially in the respiratory tract is highly limited. We developed a nonhuman primate model to probe the virus-specific antibody response in infants following infection with influenza virus. Infection of infants resulted in more pulmonary damage and higher viral loads compared to adults. While the systemic IgG antibody response was similar in infant and adult animals, the response in the upper respiratory tract of the infant was compromised. This lower response was associated with an increased prevalence of Treg cells and low levels of BALT. These data suggest a defect in the ability to produce effective virus-specific antibody responses at the local infection site is a contributor to increased pulmonary damage in the at-risk infant population.
ISSN:0042-6822
1096-0341
1096-0341
DOI:10.1016/j.virol.2014.12.007