Identification of serum sirtuins as novel noninvasive protein markers for frailty

Summary Frailty has emerged as a major health issue among older patients. A consensus on definition and diagnosis is yet to be achieved. Various biochemical abnormalities have been reported in frailty. Activation of sirtuins, a conserved family of NAD‐dependent proteins, is one of the many mimics of...

Full description

Saved in:
Bibliographic Details
Published in:Aging cell 2014-12, Vol.13 (6), p.975-980
Main Authors: Kumar, Rahul, Mohan, Navinath, Upadhyay, Ashish Datt, Singh, Amrendra Pratap, Sahu, Vishal, Dwivedi, Sadanand, Dey, Aparajit B., Dey, Sharmistha
Format: Article
Language:English
Subjects:
Aged
Aged, 80 and over
Analysis
biomarker
Biomarkers - blood
Comorbidity
Diabetes
Diagnosis
Female
Frail Elderly
frailty
Health aspects
Humans
Hypertension
Male
Original
Proteins
serum
sirtuin
Sirtuins - blood
Surface Plasmon Resonance
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Summary Frailty has emerged as a major health issue among older patients. A consensus on definition and diagnosis is yet to be achieved. Various biochemical abnormalities have been reported in frailty. Activation of sirtuins, a conserved family of NAD‐dependent proteins, is one of the many mimics of calorie restriction which improves lifespan and health in experimental animals. In this cross‐sectional study, we assessed the circulating sirtuin levels in 119 (59.5%) nonfrail and 81 (40.5%) frail individuals, diagnosed by Fried's criteria. Serum SIRT1, SIRT2, and SIRT3 were estimated by surface plasmon resonance (SPR) and Western blot. Serum sirtuins level in mean+SD; SIRT1 (nonfrail –4.67 ± 0.48 ng/μL; frail – 3.72 ± 0.48 ng/μL; P 
ISSN:1474-9718
1474-9726
DOI:10.1111/acel.12260