Theranostic USPIO-Loaded Microbubbles for Mediating and Monitoring Blood-Brain Barrier Permeation

Efficient and safe drug delivery across the blood‐brain barrier (BBB) remains one of the major challenges of biomedical and (nano‐) pharmaceutical research. Here, it is demonstrated that poly(butyl cyanoacrylate)‐based microbubbles (MB), carrying ultrasmall superparamagnetic iron oxide (USPIO) nanop...

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Bibliographic Details
Published in:Advanced functional materials 2015-01, Vol.25 (1), p.36-43
Main Authors: Lammers, Twan, Koczera, Patrick, Fokong, Stanley, Gremse, Felix, Ehling, Josef, Vogt, Michael, Pich, Andrij, Storm, Gert, van Zandvoort, Marc, Kiessling, Fabian
Format: Article
Language:English
Subjects:
Blood-brain barrier
Brain
drug delivery
Drug delivery systems
hybrid materials
magnetic nanoparticles
medical applications
Monitoring
Monitors
Penetration
Permeation
Shells
stimuli-responsive materials
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Summary:Efficient and safe drug delivery across the blood‐brain barrier (BBB) remains one of the major challenges of biomedical and (nano‐) pharmaceutical research. Here, it is demonstrated that poly(butyl cyanoacrylate)‐based microbubbles (MB), carrying ultrasmall superparamagnetic iron oxide (USPIO) nanoparticles within their shell, can be used to mediate and monitor BBB permeation. Upon exposure to transcranial ultrasound pulses, USPIO‐MB are destroyed, resulting in acoustic forces inducing vessel permeability. At the same time, USPIO are released from the MB shell, they extravasate across the permeabilized BBB and they accumulate in extravascular brain tissue, thereby providing non‐invasive R 2*‐based magnetic resonance imaging information on the extent of BBB opening. Quantitative changes in R 2* relaxometry are in good agreement with 2D and 3D microscopy results on the extravascular deposition of the macromolecular model drug fluorescein isothiocyanate (FITC)‐dextran into the brain. Such theranostic materials and methods are considered to be useful for mediating and monitoring drug delivery across the BBB and for enabling safe and efficient treatment of CNS disorders. Polymer‐based microbubbles containing ultrasmall superparamagnetic iron oxide (USPIO) nanoparticles within their shell can be used to simultaneously mediate and monitor blood‐brain barrier (BBB) permeation and to enable efficient macromolecular (model) drug delivery into the central nervous system.
ISSN:1616-301X
1616-3028
DOI:10.1002/adfm.201401199