Changes of sFas and sFasL, oxidative stress markers in serum and follicular fluid of patients undergoing IVF

Purpose The Fas-Fas Ligand interaction is one of the essential events for the induction of apoptosis whereas the exact role of their soluble forms in the reproductive system is still not fully understood. Also oxidative stress in the pathogenesis of infertility causing diseases in women and has been...

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Bibliographic Details
Published in:Journal of assisted reproduction and genetics 2015-02, Vol.32 (2), p.233-241
Main Authors: Pekel, Aslıhan, Gönenç, Aymelek, Turhan, Nilgün Öztürk, Kafalı, Hasan
Format: Article
Language:English
Subjects:
Adult
Antioxidants
Antioxidants - metabolism
Apoptosis
Assisted Reproduction Technologies
Biomarkers - analysis
Biomarkers - blood
Biomarkers - metabolism
Case-Control Studies
Endometriosis
Endometriosis - metabolism
Enzymes
Fas Ligand Protein - analysis
Fas Ligand Protein - blood
fas Receptor - analysis
fas Receptor - blood
Female
Fertilization in Vitro
Follicular Fluid - metabolism
Gynecology
Human Genetics
Humans
Infertility
Infertility, Female - blood
Infertility, Female - etiology
Ligands
Lipid Peroxidation
Medicine
Medicine & Public Health
Obstetrics
Ovaries
Oxidative Stress
Pathogenesis
Polycystic ovary syndrome
Pregnancy
Proteins
Reproductive Medicine
Reproductive system
Signal transduction
Superoxide Dismutase - metabolism
Womens health
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Summary:Purpose The Fas-Fas Ligand interaction is one of the essential events for the induction of apoptosis whereas the exact role of their soluble forms in the reproductive system is still not fully understood. Also oxidative stress in the pathogenesis of infertility causing diseases in women and has been suggested as one of the important factors that negatively affect IVF outcome. In this study, our aim was to evaluate serum and follicular fluid levels of soluble Fas soluble Fas Ligand, malondialdehyde, superoxide dismutase and total antioxidant capacity in patients undergoing IVF and compared with controls. Methods This study included 109 patients. Patients were classified as unexplained infertility ( N  = 31), PCOS ( N  = 19), tubal factor ( N  = 9) and endometriosis ( N  = 10) and compared with male factor infertility ( N  = 40) that was the control group. sFas and sFasL levels were measured by immunoassay method. MDA, SOD and TAC levels were measured by colorimetric method. Results Patients with unexplained infertility, PCOS and tubal factor had significantly lower sFas levels compared with their controls (respectively, p  
ISSN:1058-0468
1573-7330
DOI:10.1007/s10815-014-0396-8