Curcumin Mitigates Accelerated Aging after Irradiation in Drosophila by Reducing Oxidative Stress

Curcumin, belonging to a class of natural phenol compounds, has been extensively studied due to its antioxidative, anticancer, anti-inflammatory, and antineurodegenerative effects. Recently, it has been shown to exert dual activities after irradiation, radioprotection, and radiosensitization. Here,...

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Bibliographic Details
Published in:BioMed research international 2015-01, Vol.2015 (2015), p.1-8
Main Authors: Jin, Young Woo, Park, Sunhoo, Lee, Kyu-Sun, Yu, Mira, Seong, Ki Moon, Min, Kyung-Jin
Format: Article
Language:English
Subjects:
Aging
Aging - drug effects
Animals
Antioxidants
Cancer
Cancer therapies
Chromosomes
Curcumin - pharmacology
Deoxyribonucleic acid
DNA
DNA Damage
Drosophila
Drosophila melanogaster - drug effects
Drosophila melanogaster - physiology
Drosophila melanogaster - radiation effects
Drosophila Proteins - metabolism
Ethanol
Female
Free radicals
Gamma Rays
Health aspects
Insects
Lipid peroxidation
Longevity - drug effects
Longevity - radiation effects
Lymphocytes
Observations
Oxidative stress
Oxidative Stress - drug effects
Oxidative Stress - radiation effects
Phenotype
Protein Carbonylation - drug effects
Radiation therapy
Reactive Oxygen Species - metabolism
Rodents
Science
Sucrose
Turmeric
Wings, Animal - drug effects
Wings, Animal - radiation effects
Yeast
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Summary:Curcumin, belonging to a class of natural phenol compounds, has been extensively studied due to its antioxidative, anticancer, anti-inflammatory, and antineurodegenerative effects. Recently, it has been shown to exert dual activities after irradiation, radioprotection, and radiosensitization. Here, we investigated the protective effect of curcumin against radiation damage using D. melanogaster. Pretreatment with curcumin (100 μ M) recovered the shortened lifespan caused by irradiation and increased eclosion rate. Flies subjected to high-dose irradiation showed a mutant phenotype of outstretched wings, whereas curcumin pretreatment reduced incidence of the mutant phenotype. Protein carbonylation and formation of γ H2Ax foci both increased following high-dose irradiation most likely due to generation of reactive oxygen species. Curcumin pretreatment reduced the amount of protein carbonylation as well as formation of γ H2Ax foci. Therefore, we suggest that curcumin acts as an oxidative stress reducer as well as an effective protective agent against radiation damage.
ISSN:2314-6133
2314-6141
DOI:10.1155/2015/425380