Association of IL-6 Polymorphism -174G/C and Metabolic Syndrome in Hypertensive Patients

• Published in: BioMed research international 2015-01, Vol.2015 (2015), p.1-6
• Main Authors: Rodrigues, Cassio Jose de Oliveira, Dalboni, Maria Aparecida, Quinto, Beata Marie Redublo, Teixeira, Andrei Alkmim, Batista, Marcelo Costa
• Format: Article
• Language: English
• Subjects: Aged; Alleles; Angina pectoris; Apolipoproteins; Blood pressure; Body mass index; Cardiovascular disease; Cholesterol; Comparative analysis; Complications and side effects; Cytokines; Diabetes Mellitus - genetics; Diabetes Mellitus - pathology; Enzymes; Female; Genetic aspects; Genetic Association Studies; Genetic polymorphisms; Genetic Predisposition to Disease; Genotype; Genotype & phenotype; Health aspects; High density lipoprotein; Humans; Hypertension; Hypertension - complications; Hypertension - genetics; Hypertension - pathology; Immunoassay; Interleukin-6; Interleukin-6 - genetics; Low density lipoprotein; Male; Medical records; Metabolic syndrome; Metabolic Syndrome - complications; Metabolic Syndrome - genetics; Metabolic Syndrome - pathology; Metabolic syndrome X; Middle Aged; Nephrology; Obesity; Polymorphism; Polymorphism, Single Nucleotide; Statistical analysis; Vein & artery diseases
• ISSN: 2314-6133; 2314-6141
• DOI: 10.1155/2015/927589

Introduction. Visceral obesity, the central core of metabolic syndrome (MetS), is conceived as the pathogenic basis of an increased cardiovascular burden and is related with changes in cytokines. We investigated whether IL-6-174G/C gene polymorphism is associated with MetS prevalence in hypertensive patients. Method. A population of hypertensive patients was included and stratified by the presence of MetS according to IDF criteria and evaluated by Framingham risk score. The IL-6-174G/C genotyping was performed by polymerase chain reaction and the prevalence of MetS was compared between “C” carrier and “non-C” carrier groups. Results. From an original sample of 664 patients, 612 (34.2% men, age 57.3 ± 10.1, 30.4% diabetics) were included. MetS was diagnosed in 51.3% of total population and “C” carriers demonstrated high prevalence of MetS ( P < 0.05 ) and each of its components. On binary logistic regression, it was observed that the IL-6 polymorphism was independently associated with occurrence of MetS, even after adjusting for covariates (OR 1.13–2.37, 95% CI, P < 0.05 ). Conclusion. The C allele at the -174 locus of IL-6 gene is independently associated with the occurrence of metabolic syndrome, emphasizing the importance of inflammatory genetic background in the pathogenesis of visceral obesity and related cardiovascular burden.