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Circulating Cytokines and Alarmins Associated with Placental Inflammation in High-Risk Pregnancies
Problem Inflammation during pregnancy has devastating consequences for the placenta and fetus. These events are incompletely understood, thereby hampering screening and treatment. Method of study The inflammatory profile of villous tissue was studied in pregnancies at high‐risk of placental dysfunct...
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| Published in: | American journal of reproductive immunology (1989) 2014-10, Vol.72 (4), p.422-434 |
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| Main Authors: | , , , , , , |
| Format: | Article |
| Language: | English |
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| cited_by | cdi_FETCH-LOGICAL-c5844-99c66d068bd5c4642b8175ce8a42ba92b077621192bded98bfd6fd6a599bf58f3 |
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| cites | cdi_FETCH-LOGICAL-c5844-99c66d068bd5c4642b8175ce8a42ba92b077621192bded98bfd6fd6a599bf58f3 |
| container_end_page | 434 |
| container_issue | 4 |
| container_start_page | 422 |
| container_title | American journal of reproductive immunology (1989) |
| container_volume | 72 |
| creator | Girard, Sylvie Heazell, Alexander E. P. Derricott, Hayley Allan, Stuart M. Sibley, Colin P. Abrahams, Vikki M. Jones, Rebecca L. |
| description | Problem
Inflammation during pregnancy has devastating consequences for the placenta and fetus. These events are incompletely understood, thereby hampering screening and treatment.
Method of study
The inflammatory profile of villous tissue was studied in pregnancies at high‐risk of placental dysfunction and compared to uncomplicated pregnancies. The systemic inflammatory profile was assessed in matched maternal serum samples in cases of reduced fetal movements (RFM).
Results
Placentas from RFM pregnancies had a unique inflammatory profile characterized by increased interleukin (IL)‐1 receptor antagonist and decreased IL‐10 expression, concomitant with increased numbers of placental macrophages. This aberrant cytokine profile was evident in maternal serum in RFM, as were increased levels of alarmins (uric acid, HMGB1, cell‐free fetal DNA).
Conclusion
This distinct inflammatory profile at the maternal‐fetal interface, mirrored in maternal serum, could represent biomarkers of placental inflammation and could offer novel therapeutic options to protect the placenta and fetus from an adverse maternal environment. |
| doi_str_mv | 10.1111/aji.12274 |
| format | article |
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Inflammation during pregnancy has devastating consequences for the placenta and fetus. These events are incompletely understood, thereby hampering screening and treatment.
Method of study
The inflammatory profile of villous tissue was studied in pregnancies at high‐risk of placental dysfunction and compared to uncomplicated pregnancies. The systemic inflammatory profile was assessed in matched maternal serum samples in cases of reduced fetal movements (RFM).
Results
Placentas from RFM pregnancies had a unique inflammatory profile characterized by increased interleukin (IL)‐1 receptor antagonist and decreased IL‐10 expression, concomitant with increased numbers of placental macrophages. This aberrant cytokine profile was evident in maternal serum in RFM, as were increased levels of alarmins (uric acid, HMGB1, cell‐free fetal DNA).
Conclusion
This distinct inflammatory profile at the maternal‐fetal interface, mirrored in maternal serum, could represent biomarkers of placental inflammation and could offer novel therapeutic options to protect the placenta and fetus from an adverse maternal environment.</description><identifier>ISSN: 1046-7408</identifier><identifier>EISSN: 1600-0897</identifier><identifier>DOI: 10.1111/aji.12274</identifier><identifier>PMID: 24867252</identifier><language>eng</language><publisher>Denmark: Blackwell Publishing Ltd</publisher><subject>Adolescent ; Adult ; Biomarkers - blood ; Clinical Aspects of Reproductive Immunology ; Cytokines - blood ; Female ; Fetuses ; High-risk pregnancy ; HMGB1 Protein - blood ; Humans ; Inflammation ; Inflammation - blood ; Interleukin 1 Receptor Antagonist Protein - blood ; Interleukin-10 - blood ; Interleukin-18 - blood ; Interleukin-1alpha - blood ; Interleukin-1beta - blood ; Macrophages - immunology ; Placenta - immunology ; Placenta - physiopathology ; placental dysfunction ; Pregnancy ; Pregnancy Complications - blood ; Pregnancy Complications - physiopathology ; Pregnancy, High-Risk - blood ; Prenatal development ; stillbirth ; Young Adult</subject><ispartof>American journal of reproductive immunology (1989), 2014-10, Vol.72 (4), p.422-434</ispartof><rights>2014 The Authors. Published by John Wiley & Sons Ltd.</rights><rights>2014 The Authors. American Journal of Reproductive Immunology Published by John Wiley & Sons Ltd.</rights><rights>Copyright © 2014 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd.</rights><rights>2014 The Authors. Published by John Wiley & Sons Ltd. 2014</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c5844-99c66d068bd5c4642b8175ce8a42ba92b077621192bded98bfd6fd6a599bf58f3</citedby><cites>FETCH-LOGICAL-c5844-99c66d068bd5c4642b8175ce8a42ba92b077621192bded98bfd6fd6a599bf58f3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>230,314,780,784,885,27924,27925</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/24867252$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Girard, Sylvie</creatorcontrib><creatorcontrib>Heazell, Alexander E. P.</creatorcontrib><creatorcontrib>Derricott, Hayley</creatorcontrib><creatorcontrib>Allan, Stuart M.</creatorcontrib><creatorcontrib>Sibley, Colin P.</creatorcontrib><creatorcontrib>Abrahams, Vikki M.</creatorcontrib><creatorcontrib>Jones, Rebecca L.</creatorcontrib><title>Circulating Cytokines and Alarmins Associated with Placental Inflammation in High-Risk Pregnancies</title><title>American journal of reproductive immunology (1989)</title><addtitle>Am J Reprod Immunol</addtitle><description>Problem
Inflammation during pregnancy has devastating consequences for the placenta and fetus. These events are incompletely understood, thereby hampering screening and treatment.
Method of study
The inflammatory profile of villous tissue was studied in pregnancies at high‐risk of placental dysfunction and compared to uncomplicated pregnancies. The systemic inflammatory profile was assessed in matched maternal serum samples in cases of reduced fetal movements (RFM).
Results
Placentas from RFM pregnancies had a unique inflammatory profile characterized by increased interleukin (IL)‐1 receptor antagonist and decreased IL‐10 expression, concomitant with increased numbers of placental macrophages. This aberrant cytokine profile was evident in maternal serum in RFM, as were increased levels of alarmins (uric acid, HMGB1, cell‐free fetal DNA).
Conclusion
This distinct inflammatory profile at the maternal‐fetal interface, mirrored in maternal serum, could represent biomarkers of placental inflammation and could offer novel therapeutic options to protect the placenta and fetus from an adverse maternal environment.</description><subject>Adolescent</subject><subject>Adult</subject><subject>Biomarkers - blood</subject><subject>Clinical Aspects of Reproductive Immunology</subject><subject>Cytokines - blood</subject><subject>Female</subject><subject>Fetuses</subject><subject>High-risk pregnancy</subject><subject>HMGB1 Protein - blood</subject><subject>Humans</subject><subject>Inflammation</subject><subject>Inflammation - blood</subject><subject>Interleukin 1 Receptor Antagonist Protein - blood</subject><subject>Interleukin-10 - blood</subject><subject>Interleukin-18 - blood</subject><subject>Interleukin-1alpha - blood</subject><subject>Interleukin-1beta - blood</subject><subject>Macrophages - immunology</subject><subject>Placenta - immunology</subject><subject>Placenta - physiopathology</subject><subject>placental dysfunction</subject><subject>Pregnancy</subject><subject>Pregnancy Complications - blood</subject><subject>Pregnancy Complications - physiopathology</subject><subject>Pregnancy, High-Risk - blood</subject><subject>Prenatal development</subject><subject>stillbirth</subject><subject>Young Adult</subject><issn>1046-7408</issn><issn>1600-0897</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2014</creationdate><recordtype>article</recordtype><sourceid>24P</sourceid><recordid>eNqNkV2LEzEUhoMo7ode-Ack4I1ezG6SyeTjRqhVu12KLqJ4GTKZTJs2k9lNZnbtvze1u0UFwRDIIXnel3PyAvACozOc17leuzNMCKePwDFmCBVISP4414iyglMkjsBJSmuE8n3Jn4IjQgXjpCLHoJ66aEavBxeWcLod-o0LNkEdGjjxOnYuJDhJqTdOD7aBd25YwSuvjQ2D9nAeWq-7Lqv7AF2AF265Kr64tIFX0S6DDsbZ9Aw8abVP9vn9eQq-ffzwdXpRLD7P5tPJojCVoLSQ0jDWICbqpjKUUVILzCtjhc6llqRGnDOCca4a20hRtw3LW1dS1m0l2vIUvN37Xo91Z5tdi1F7dR1dp-NW9dqpP1-CW6llf6toySQuRTZ4fW8Q-5vRpkF1LhnrvQ62H5PCFWOCslKy_0ExJrIsd-irv9B1P8aQf2JHIZ5DEjRTb_aUiX1K0baHvjFSu5BVDln9CjmzL38f9EA-pJqB8z1w57zd_ttJTS7nD5bFXuHSYH8cFDpuFOMlr9T3TzNFFosZIe_eq8vyJ3uKwFs</recordid><startdate>201410</startdate><enddate>201410</enddate><creator>Girard, Sylvie</creator><creator>Heazell, Alexander E. P.</creator><creator>Derricott, Hayley</creator><creator>Allan, Stuart M.</creator><creator>Sibley, Colin P.</creator><creator>Abrahams, Vikki M.</creator><creator>Jones, Rebecca L.</creator><general>Blackwell Publishing Ltd</general><general>Wiley Subscription Services, Inc</general><general>BlackWell Publishing Ltd</general><scope>BSCLL</scope><scope>24P</scope><scope>WIN</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7T5</scope><scope>7U9</scope><scope>H94</scope><scope>K9.</scope><scope>7X8</scope><scope>5PM</scope></search><sort><creationdate>201410</creationdate><title>Circulating Cytokines and Alarmins Associated with Placental Inflammation in High-Risk Pregnancies</title><author>Girard, Sylvie ; Heazell, Alexander E. P. ; Derricott, Hayley ; Allan, Stuart M. ; Sibley, Colin P. ; Abrahams, Vikki M. ; Jones, Rebecca L.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c5844-99c66d068bd5c4642b8175ce8a42ba92b077621192bded98bfd6fd6a599bf58f3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2014</creationdate><topic>Adolescent</topic><topic>Adult</topic><topic>Biomarkers - blood</topic><topic>Clinical Aspects of Reproductive Immunology</topic><topic>Cytokines - blood</topic><topic>Female</topic><topic>Fetuses</topic><topic>High-risk pregnancy</topic><topic>HMGB1 Protein - blood</topic><topic>Humans</topic><topic>Inflammation</topic><topic>Inflammation - blood</topic><topic>Interleukin 1 Receptor Antagonist Protein - blood</topic><topic>Interleukin-10 - blood</topic><topic>Interleukin-18 - blood</topic><topic>Interleukin-1alpha - blood</topic><topic>Interleukin-1beta - blood</topic><topic>Macrophages - immunology</topic><topic>Placenta - immunology</topic><topic>Placenta - physiopathology</topic><topic>placental dysfunction</topic><topic>Pregnancy</topic><topic>Pregnancy Complications - blood</topic><topic>Pregnancy Complications - physiopathology</topic><topic>Pregnancy, High-Risk - blood</topic><topic>Prenatal development</topic><topic>stillbirth</topic><topic>Young Adult</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Girard, Sylvie</creatorcontrib><creatorcontrib>Heazell, Alexander E. P.</creatorcontrib><creatorcontrib>Derricott, Hayley</creatorcontrib><creatorcontrib>Allan, Stuart M.</creatorcontrib><creatorcontrib>Sibley, Colin P.</creatorcontrib><creatorcontrib>Abrahams, Vikki M.</creatorcontrib><creatorcontrib>Jones, Rebecca L.</creatorcontrib><collection>Istex</collection><collection>Wiley-Blackwell Open Access Collection</collection><collection>Wiley-Blackwell Backfiles (Open access)</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Immunology Abstracts</collection><collection>Virology and AIDS Abstracts</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>American journal of reproductive immunology (1989)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Girard, Sylvie</au><au>Heazell, Alexander E. P.</au><au>Derricott, Hayley</au><au>Allan, Stuart M.</au><au>Sibley, Colin P.</au><au>Abrahams, Vikki M.</au><au>Jones, Rebecca L.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Circulating Cytokines and Alarmins Associated with Placental Inflammation in High-Risk Pregnancies</atitle><jtitle>American journal of reproductive immunology (1989)</jtitle><addtitle>Am J Reprod Immunol</addtitle><date>2014-10</date><risdate>2014</risdate><volume>72</volume><issue>4</issue><spage>422</spage><epage>434</epage><pages>422-434</pages><issn>1046-7408</issn><eissn>1600-0897</eissn><abstract>Problem
Inflammation during pregnancy has devastating consequences for the placenta and fetus. These events are incompletely understood, thereby hampering screening and treatment.
Method of study
The inflammatory profile of villous tissue was studied in pregnancies at high‐risk of placental dysfunction and compared to uncomplicated pregnancies. The systemic inflammatory profile was assessed in matched maternal serum samples in cases of reduced fetal movements (RFM).
Results
Placentas from RFM pregnancies had a unique inflammatory profile characterized by increased interleukin (IL)‐1 receptor antagonist and decreased IL‐10 expression, concomitant with increased numbers of placental macrophages. This aberrant cytokine profile was evident in maternal serum in RFM, as were increased levels of alarmins (uric acid, HMGB1, cell‐free fetal DNA).
Conclusion
This distinct inflammatory profile at the maternal‐fetal interface, mirrored in maternal serum, could represent biomarkers of placental inflammation and could offer novel therapeutic options to protect the placenta and fetus from an adverse maternal environment.</abstract><cop>Denmark</cop><pub>Blackwell Publishing Ltd</pub><pmid>24867252</pmid><doi>10.1111/aji.12274</doi><tpages>13</tpages><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 1046-7408 |
| ispartof | American journal of reproductive immunology (1989), 2014-10, Vol.72 (4), p.422-434 |
| issn | 1046-7408 1600-0897 |
| language | eng |
| recordid | cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_4369138 |
| source | Wiley |
| subjects | Adolescent Adult Biomarkers - blood Clinical Aspects of Reproductive Immunology Cytokines - blood Female Fetuses High-risk pregnancy HMGB1 Protein - blood Humans Inflammation Inflammation - blood Interleukin 1 Receptor Antagonist Protein - blood Interleukin-10 - blood Interleukin-18 - blood Interleukin-1alpha - blood Interleukin-1beta - blood Macrophages - immunology Placenta - immunology Placenta - physiopathology placental dysfunction Pregnancy Pregnancy Complications - blood Pregnancy Complications - physiopathology Pregnancy, High-Risk - blood Prenatal development stillbirth Young Adult |
| title | Circulating Cytokines and Alarmins Associated with Placental Inflammation in High-Risk Pregnancies |
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