Does obesity or hyperuricemia influence lithogenic risk profile in children with urolithiasis?

Background There are indications that obesity and hyperuricemia may influence the formation and composition of urinary stones. The aim of our study was to determine the effect of obesity and hyperuricemia on the urinary lithogenic risk profile in a large cohort of pediatric patients. Methods The stu...

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Bibliographic Details
Published in:Pediatric nephrology (Berlin, West) West), 2015-05, Vol.30 (5), p.797-803
Main Authors: Kuroczycka-Saniutycz, Elżbieta, Porowski, Tadeusz, Protas, Piotr T., Pszczółkowska, Marta, Porowska, Halina, Kirejczyk, Jan K., Wasilewska, Anna
Format: Article
Language:English
Subjects:
Adolescent
Body mass index
Child
Complications and side effects
Creatinine
Electrolytes - urine
Female
Hospitals
Humans
Hyperuricemia
Hyperuricemia - epidemiology
Influence
Male
Medicine
Medicine & Public Health
Metabolic syndrome
Nephrology
Obesity
Obesity - epidemiology
Original
Original Article
Overweight
Patients
Pediatrics
Risk Factors
Standard scores
Teenagers
Ultrasonic imaging
Uric acid
Uric Acid - blood
Urinary stones
Urinary tract diseases
Urine
Urolithiasis - epidemiology
Urology
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Summary:Background There are indications that obesity and hyperuricemia may influence the formation and composition of urinary stones. The aim of our study was to determine the effect of obesity and hyperuricemia on the urinary lithogenic risk profile in a large cohort of pediatric patients. Methods The study population comprised 478 children with urolithiasis and 517 healthy children (reference group). We studied the effects of obesity on the lithogenic profile by dividing the patients with urolithiasis into two groups based on body mass index Z -score (patients who were overweight/obese vs. those with normal weight for age) and comparing the two groups. To study the effect of hyperuricemia on the lithogenic profile, we divided the patients with urolithiasis into two groups based on the presence or not of hyperuricemia (110 patients with urolithiasis accompanied by hyperuricemia vs. 368 patients with urolithiasis and normal serum uric acid levels) and compared the groups. Results Among the children and adolescents with urolithiasis and hyperuricemia, there was a significantly lower excretion of crystallization inhibitors (citrates, magnesium). We also found significantly negative correlations between serum uric acid levels and the urine citrate/creatinine ratio (citrate/cr.; r  = −0.30, p  
ISSN:0931-041X
1432-198X
DOI:10.1007/s00467-014-2999-9