The biology of IQGAP proteins: beyond the cytoskeleton

IQGAP scaffold proteins are evolutionarily conserved in eukaryotes and facilitate the formation of complexes that regulate cytoskeletal dynamics, intracellular signaling, and intercellular interactions. Fungal and mammalian IQGAPs are implicated in cytokinesis. IQGAP1, IQGAP2, and IQGAP3 have divers...

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Bibliographic Details
Published in:EMBO reports 2015-04, Vol.16 (4), p.427-446
Main Authors: Hedman, Andrew C, Smith, Jessica M, Sacks, David B
Format: Article
Language:English
Subjects:
Animals
biology
Blood Vessels - cytology
Blood Vessels - metabolism
Brain - cytology
Brain - metabolism
Cellular biology
Communicable Diseases - genetics
Communicable Diseases - immunology
Communicable Diseases - metabolism
Cytokinesis - genetics
Cytoskeleton
Cytoskeleton - chemistry
Cytoskeleton - metabolism
EMBO05
EMBO37
Gene Expression Regulation
GTPase-Activating Proteins - genetics
GTPase-Activating Proteins - metabolism
Humans
IQGAP1
IQGAP2
IQGAP3
Kidney - cytology
Kidney - metabolism
Lung - cytology
Lung - metabolism
Microbiology
Myocardium - cytology
Myocardium - metabolism
Physiology
Proteins
ras GTPase-Activating Proteins - genetics
ras GTPase-Activating Proteins - metabolism
Review
Reviews
Saccharomyces cerevisiae - genetics
Saccharomyces cerevisiae - metabolism
Signal Transduction
therapeutics
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Summary:IQGAP scaffold proteins are evolutionarily conserved in eukaryotes and facilitate the formation of complexes that regulate cytoskeletal dynamics, intracellular signaling, and intercellular interactions. Fungal and mammalian IQGAPs are implicated in cytokinesis. IQGAP1, IQGAP2, and IQGAP3 have diverse roles in vertebrate physiology, operating in the kidney, nervous system, cardio‐vascular system, pancreas, and lung. The functions of IQGAPs can be corrupted during oncogenesis and are usurped by microbial pathogens. Therefore, IQGAPs represent intriguing candidates for novel therapeutic agents. While modulation of the cytoskeletal architecture was initially thought to be the primary function of IQGAPs, it is now clear that they have roles beyond the cytoskeleton. This review describes contributions of IQGAPs to physiology at the organism level. Graphical Abstract IQGAP proteins regulate diverse cellular processes, including cytokinesis, migration, proliferation, and vesicle trafficking. This review discusses the roles of IQGAP proteins at the organismal level.
ISSN:1469-221X
1469-3178
DOI:10.15252/embr.201439834