Preclinical Studies on the Pharmacokinetics, Safety, and Toxicology of Oxfendazole: Toward First in Human Studies

A 2-week study in rats identified target organs of oxfendazole toxicity to be bone marrow, epididymis, liver, spleen, testis, and thymus. Female rats had greater oxfendazole exposure and exhibited toxicities at lower doses than did males. Decreased white blood cell levels, a class effect of benzimid...

Full description

Saved in:
Bibliographic Details
Published in:International journal of toxicology 2015-03, Vol.34 (2), p.129-137
Main Authors: Codd, Ellen E., Ng, Hanna H., McFarlane, Claire, Riccio, Edward S., Doppalapudi, Rupa, Mirsalis, Jon C., Horton, R. John, Gonzalez, Armando E., Garcia, H. Hugo, Gilman, Robert H.
Format: Article
Language:English
Subjects:
Administration, Oral
Animals
Anthelmintics - adverse effects
Anthelmintics - pharmacokinetics
Anthelmintics - toxicity
Benzimidazoles - adverse effects
Benzimidazoles - pharmacokinetics
Benzimidazoles - toxicity
Cardiovascular System - drug effects
Dogs
Dose-Response Relationship, Drug
Female
Leukemia L5178 - genetics
Male
Mice
Micronucleus Tests
Mutagenicity Tests
Rats
Rats, Sprague-Dawley
Citations: Items that this one cites
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:A 2-week study in rats identified target organs of oxfendazole toxicity to be bone marrow, epididymis, liver, spleen, testis, and thymus. Female rats had greater oxfendazole exposure and exhibited toxicities at lower doses than did males. Decreased white blood cell levels, a class effect of benzimidazole anthelmintics, returned to normal during the recovery period. The no observed adverse effect level was determined to be >5 but
ISSN:1091-5818
1092-874X
DOI:10.1177/1091581815569582