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Development of the zebrafish mesonephros
Summary The vertebrate kidney plays an essential role in removing metabolic waste and balancing water and salt. This is carried out by nephrons, which comprise a blood filter attached to an epithelial tubule with proximal and distal segments. In zebrafish, two nephrons are first formed as part of th...
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Published in: | Genesis (New York, N.Y. : 2000) N.Y. : 2000), 2015-03, Vol.53 (3-4), p.257-269 |
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container_title | Genesis (New York, N.Y. : 2000) |
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creator | Diep, Cuong Q. Peng, Zhenzhen Ukah, Tobechukwu K. Kelly, Paul M. Daigle, Renee V. Davidson, Alan J. |
description | Summary
The vertebrate kidney plays an essential role in removing metabolic waste and balancing water and salt. This is carried out by nephrons, which comprise a blood filter attached to an epithelial tubule with proximal and distal segments. In zebrafish, two nephrons are first formed as part of the embryonic kidney (pronephros) and hundreds are formed later to make up the adult kidney (mesonephros). Previous studies have focused on the development of the pronephros while considerably less is known about how the mesonephros is formed. Here, we characterize mesonephros development in zebrafish and examine the nephrons that form during larval metamorphosis. These nephrons, arising from proliferating progenitor cells that express the renal transcription factor genes wt1b, pax2a, and lhx1a, form on top of the pronephric tubules and develop a segmentation pattern similar to pronephric nephrons. We find that the pronephros acts as a scaffold for the mesonephros, where new nephrons fuse with the distal segments of the pronephric tubules to form the final branching network that characterizes the adult zebrafish kidney. genesis 53:257–269, 2015. © 2015 Wiley Periodicals, Inc. |
doi_str_mv | 10.1002/dvg.22846 |
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The vertebrate kidney plays an essential role in removing metabolic waste and balancing water and salt. This is carried out by nephrons, which comprise a blood filter attached to an epithelial tubule with proximal and distal segments. In zebrafish, two nephrons are first formed as part of the embryonic kidney (pronephros) and hundreds are formed later to make up the adult kidney (mesonephros). Previous studies have focused on the development of the pronephros while considerably less is known about how the mesonephros is formed. Here, we characterize mesonephros development in zebrafish and examine the nephrons that form during larval metamorphosis. These nephrons, arising from proliferating progenitor cells that express the renal transcription factor genes wt1b, pax2a, and lhx1a, form on top of the pronephric tubules and develop a segmentation pattern similar to pronephric nephrons. We find that the pronephros acts as a scaffold for the mesonephros, where new nephrons fuse with the distal segments of the pronephric tubules to form the final branching network that characterizes the adult zebrafish kidney. genesis 53:257–269, 2015. © 2015 Wiley Periodicals, Inc.</description><identifier>ISSN: 1526-954X</identifier><identifier>EISSN: 1526-968X</identifier><identifier>DOI: 10.1002/dvg.22846</identifier><identifier>PMID: 25677367</identifier><language>eng</language><publisher>United States: Blackwell Publishing Ltd</publisher><subject>Animals ; Danio rerio ; Embryo, Nonmammalian - cytology ; Embryo, Nonmammalian - physiology ; Freshwater ; Gene Expression Regulation, Developmental ; Immunoenzyme Techniques ; In Situ Hybridization ; kidney ; Kidney - embryology ; Kidney - metabolism ; Mesonephros - embryology ; Mesonephros - metabolism ; Metamorphosis, Biological ; nephron ; Nephrons - embryology ; Nephrons - metabolism ; Organogenesis - physiology ; pronephros ; Pronephros - embryology ; Pronephros - metabolism ; Zebrafish - embryology ; Zebrafish - genetics ; Zebrafish - metabolism ; Zebrafish Proteins - metabolism</subject><ispartof>Genesis (New York, N.Y. : 2000), 2015-03, Vol.53 (3-4), p.257-269</ispartof><rights>2015 Wiley Periodicals, Inc.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c5806-b1b6b2f8d197c7070c69a32c81dccba8e56e488b477a5c09f8b6bb4b1b4daee93</citedby><cites>FETCH-LOGICAL-c5806-b1b6b2f8d197c7070c69a32c81dccba8e56e488b477a5c09f8b6bb4b1b4daee93</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>230,314,780,784,885,27924,27925</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/25677367$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Diep, Cuong Q.</creatorcontrib><creatorcontrib>Peng, Zhenzhen</creatorcontrib><creatorcontrib>Ukah, Tobechukwu K.</creatorcontrib><creatorcontrib>Kelly, Paul M.</creatorcontrib><creatorcontrib>Daigle, Renee V.</creatorcontrib><creatorcontrib>Davidson, Alan J.</creatorcontrib><title>Development of the zebrafish mesonephros</title><title>Genesis (New York, N.Y. : 2000)</title><addtitle>genesis</addtitle><description>Summary
The vertebrate kidney plays an essential role in removing metabolic waste and balancing water and salt. This is carried out by nephrons, which comprise a blood filter attached to an epithelial tubule with proximal and distal segments. In zebrafish, two nephrons are first formed as part of the embryonic kidney (pronephros) and hundreds are formed later to make up the adult kidney (mesonephros). Previous studies have focused on the development of the pronephros while considerably less is known about how the mesonephros is formed. Here, we characterize mesonephros development in zebrafish and examine the nephrons that form during larval metamorphosis. These nephrons, arising from proliferating progenitor cells that express the renal transcription factor genes wt1b, pax2a, and lhx1a, form on top of the pronephric tubules and develop a segmentation pattern similar to pronephric nephrons. We find that the pronephros acts as a scaffold for the mesonephros, where new nephrons fuse with the distal segments of the pronephric tubules to form the final branching network that characterizes the adult zebrafish kidney. genesis 53:257–269, 2015. © 2015 Wiley Periodicals, Inc.</description><subject>Animals</subject><subject>Danio rerio</subject><subject>Embryo, Nonmammalian - cytology</subject><subject>Embryo, Nonmammalian - physiology</subject><subject>Freshwater</subject><subject>Gene Expression Regulation, Developmental</subject><subject>Immunoenzyme Techniques</subject><subject>In Situ Hybridization</subject><subject>kidney</subject><subject>Kidney - embryology</subject><subject>Kidney - metabolism</subject><subject>Mesonephros - embryology</subject><subject>Mesonephros - metabolism</subject><subject>Metamorphosis, Biological</subject><subject>nephron</subject><subject>Nephrons - embryology</subject><subject>Nephrons - metabolism</subject><subject>Organogenesis - physiology</subject><subject>pronephros</subject><subject>Pronephros - embryology</subject><subject>Pronephros - metabolism</subject><subject>Zebrafish - embryology</subject><subject>Zebrafish - genetics</subject><subject>Zebrafish - metabolism</subject><subject>Zebrafish Proteins - metabolism</subject><issn>1526-954X</issn><issn>1526-968X</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2015</creationdate><recordtype>article</recordtype><recordid>eNqNkUtvEzEURi1UREtgwR-oIrEpi2mvPX7NBqlKaUCKgAWQ7iyP504z7cw42En6-PW45CFaCakrW_L5jq7vR8g7CscUgJ1Uq8tjxjSXL8gBFUxmhdQXe9u74Bf75HWMVwAgNGOvyD4TUqlcqgNydIYrbP28w34x9PVwMcPhPZbB1k2cDTuMvsf5LPj4hrysbRvx7eYckJ_nn36MPmeTb-Mvo9NJ5oQGmZW0lCWrdUUL5RQocLKwOXOaVs6VVqOQyLUuuVJWOChqnfiSpxivLGKRD8jHtXe-LDusXJor2NbMQ9PZcGe8bczjl76ZmUu_MpxTphkkwdFGEPzvJcaF6ZrosG1tj34ZDZUauASe62egSuYcKBMJff8EvfLL0KdNPFAiB6koS9SHNeXSxmLAejc3BfNQlUlVmb9VJfbw34_uyG03CThZAzdNi3f_N5mzX-OtMlsnmrjA213ChmuTfEqY6dexYcV0-p3BxIzzP6j3rFw</recordid><startdate>201503</startdate><enddate>201503</enddate><creator>Diep, Cuong Q.</creator><creator>Peng, Zhenzhen</creator><creator>Ukah, Tobechukwu K.</creator><creator>Kelly, Paul M.</creator><creator>Daigle, Renee V.</creator><creator>Davidson, Alan J.</creator><general>Blackwell Publishing Ltd</general><general>Wiley Subscription Services, Inc</general><scope>BSCLL</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QL</scope><scope>7QP</scope><scope>7T7</scope><scope>7TK</scope><scope>7TM</scope><scope>7U9</scope><scope>8FD</scope><scope>C1K</scope><scope>FR3</scope><scope>H94</scope><scope>M7N</scope><scope>P64</scope><scope>RC3</scope><scope>7X8</scope><scope>F1W</scope><scope>H95</scope><scope>L.G</scope><scope>5PM</scope></search><sort><creationdate>201503</creationdate><title>Development of the zebrafish mesonephros</title><author>Diep, Cuong Q. ; Peng, Zhenzhen ; Ukah, Tobechukwu K. ; Kelly, Paul M. ; Daigle, Renee V. ; Davidson, Alan J.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c5806-b1b6b2f8d197c7070c69a32c81dccba8e56e488b477a5c09f8b6bb4b1b4daee93</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2015</creationdate><topic>Animals</topic><topic>Danio rerio</topic><topic>Embryo, Nonmammalian - cytology</topic><topic>Embryo, Nonmammalian - physiology</topic><topic>Freshwater</topic><topic>Gene Expression Regulation, Developmental</topic><topic>Immunoenzyme Techniques</topic><topic>In Situ Hybridization</topic><topic>kidney</topic><topic>Kidney - embryology</topic><topic>Kidney - metabolism</topic><topic>Mesonephros - embryology</topic><topic>Mesonephros - metabolism</topic><topic>Metamorphosis, Biological</topic><topic>nephron</topic><topic>Nephrons - embryology</topic><topic>Nephrons - metabolism</topic><topic>Organogenesis - physiology</topic><topic>pronephros</topic><topic>Pronephros - embryology</topic><topic>Pronephros - metabolism</topic><topic>Zebrafish - embryology</topic><topic>Zebrafish - genetics</topic><topic>Zebrafish - metabolism</topic><topic>Zebrafish Proteins - metabolism</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Diep, Cuong Q.</creatorcontrib><creatorcontrib>Peng, Zhenzhen</creatorcontrib><creatorcontrib>Ukah, Tobechukwu K.</creatorcontrib><creatorcontrib>Kelly, Paul M.</creatorcontrib><creatorcontrib>Daigle, Renee V.</creatorcontrib><creatorcontrib>Davidson, Alan J.</creatorcontrib><collection>Istex</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Bacteriology Abstracts (Microbiology B)</collection><collection>Calcium & Calcified Tissue Abstracts</collection><collection>Industrial and Applied Microbiology Abstracts (Microbiology A)</collection><collection>Neurosciences Abstracts</collection><collection>Nucleic Acids Abstracts</collection><collection>Virology and AIDS Abstracts</collection><collection>Technology Research Database</collection><collection>Environmental Sciences and Pollution Management</collection><collection>Engineering Research Database</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>Algology Mycology and Protozoology Abstracts (Microbiology C)</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>Genetics Abstracts</collection><collection>MEDLINE - Academic</collection><collection>ASFA: Aquatic Sciences and Fisheries Abstracts</collection><collection>Aquatic Science & Fisheries Abstracts (ASFA) 1: Biological Sciences & Living Resources</collection><collection>Aquatic Science & Fisheries Abstracts (ASFA) Professional</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Genesis (New York, N.Y. : 2000)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Diep, Cuong Q.</au><au>Peng, Zhenzhen</au><au>Ukah, Tobechukwu K.</au><au>Kelly, Paul M.</au><au>Daigle, Renee V.</au><au>Davidson, Alan J.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Development of the zebrafish mesonephros</atitle><jtitle>Genesis (New York, N.Y. : 2000)</jtitle><addtitle>genesis</addtitle><date>2015-03</date><risdate>2015</risdate><volume>53</volume><issue>3-4</issue><spage>257</spage><epage>269</epage><pages>257-269</pages><issn>1526-954X</issn><eissn>1526-968X</eissn><abstract>Summary
The vertebrate kidney plays an essential role in removing metabolic waste and balancing water and salt. This is carried out by nephrons, which comprise a blood filter attached to an epithelial tubule with proximal and distal segments. In zebrafish, two nephrons are first formed as part of the embryonic kidney (pronephros) and hundreds are formed later to make up the adult kidney (mesonephros). Previous studies have focused on the development of the pronephros while considerably less is known about how the mesonephros is formed. Here, we characterize mesonephros development in zebrafish and examine the nephrons that form during larval metamorphosis. These nephrons, arising from proliferating progenitor cells that express the renal transcription factor genes wt1b, pax2a, and lhx1a, form on top of the pronephric tubules and develop a segmentation pattern similar to pronephric nephrons. We find that the pronephros acts as a scaffold for the mesonephros, where new nephrons fuse with the distal segments of the pronephric tubules to form the final branching network that characterizes the adult zebrafish kidney. genesis 53:257–269, 2015. © 2015 Wiley Periodicals, Inc.</abstract><cop>United States</cop><pub>Blackwell Publishing Ltd</pub><pmid>25677367</pmid><doi>10.1002/dvg.22846</doi><tpages>13</tpages><oa>free_for_read</oa></addata></record> |
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subjects | Animals Danio rerio Embryo, Nonmammalian - cytology Embryo, Nonmammalian - physiology Freshwater Gene Expression Regulation, Developmental Immunoenzyme Techniques In Situ Hybridization kidney Kidney - embryology Kidney - metabolism Mesonephros - embryology Mesonephros - metabolism Metamorphosis, Biological nephron Nephrons - embryology Nephrons - metabolism Organogenesis - physiology pronephros Pronephros - embryology Pronephros - metabolism Zebrafish - embryology Zebrafish - genetics Zebrafish - metabolism Zebrafish Proteins - metabolism |
title | Development of the zebrafish mesonephros |
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