Alzheimer’s Pathogenesis and Its Link to the Mitochondrion

Alzheimer’s disease (AD) is the most common form of dementia in the elderly. This neurodegenerative disorder is clinically characterized by impairment of cognitive functions and changes in behaviour and personality. The pathogenesis of AD is still unclear. Recent evidence supports some role of mitoc...

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Bibliographic Details
Published in:Oxidative medicine and cellular longevity 2015-01, Vol.2015 (2015), p.1-8
Main Authors: Bonuccelli, Ubaldo, Siciliano, Gabriele, Ienco, Elena Caldarazzo, Orsucci, D., Simoncini, C., Mancuso, Michelangelo
Format: Article
Language:English
Subjects:
Advertising executives
Alzheimer Disease - metabolism
Alzheimer Disease - pathology
Alzheimer's disease
Amyloid beta-Peptides - metabolism
Brain
Cognitive ability
Dehydrogenases
Dementia
DNA, Mitochondrial - metabolism
Energy Metabolism
Enzymes
Free radicals
Glucose
Humans
Hypotheses
Memory
Metabolism
Metabolites
Mitochondria
Mitochondria - metabolism
Mitochondrial DNA
Neurotoxicity
Oxidative Stress
Pathogenesis
Pathology
Reactive Oxygen Species - metabolism
Review
Studies
tau Proteins - metabolism
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Summary:Alzheimer’s disease (AD) is the most common form of dementia in the elderly. This neurodegenerative disorder is clinically characterized by impairment of cognitive functions and changes in behaviour and personality. The pathogenesis of AD is still unclear. Recent evidence supports some role of mitochondria dysfunction and oxidative stress in the development of the neurodegenerative process. In this review, we discuss the role of mitochondrial dysfunction in AD, focusing on the mechanisms that lead to mitochondrial impairment, oxidative stress, and neurodegeneration, a “vicious circle” that ends in dementia.
ISSN:1942-0900
1942-0994
DOI:10.1155/2015/803942