Metabolism of circulating disaccharides in man and the rat

The metabolism of circulating disaccharides was studied in adult humans and rats. After iv infusions of 10 g of either lactose, sucrose, or maltose in four adults, no rise in blood glucose was noted. A mean of 8.7+/-1.89 g of the lactose and 6.3+/-1.39 g of the sucrose was excreted in the 24-hour ur...

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Bibliographic Details
Published in:The Journal of clinical investigation 1967-04, Vol.46 (4), p.499-505
Main Authors: Weser, E, Sleisenger, M H
Format: Article
Language:English
Subjects:
Animals
Blood Glucose - analysis
Brain - enzymology
Carbon Isotopes
Chromatography, Paper
Glucose - analysis
Glucosidases - analysis
Glucosidases - blood
Humans
Intestinal Mucosa - enzymology
Intestine, Small - cytology
Kidney - enzymology
Lactose - metabolism
Lactose - urine
Liver - enzymology
Male
Maltose - metabolism
Maltose - urine
Muscles - enzymology
Pancreas - enzymology
Rats
Spleen - enzymology
Sucrose - metabolism
Sucrose - urine
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Summary:The metabolism of circulating disaccharides was studied in adult humans and rats. After iv infusions of 10 g of either lactose, sucrose, or maltose in four adults, no rise in blood glucose was noted. A mean of 8.7+/-1.89 g of the lactose and 6.3+/-1.39 g of the sucrose was excreted in the 24-hour urine sample. Only 0.11+/-0.03 g of the infused maltose was recovered in the urine, suggesting that the maltose was metabolized.After injection of (14)C-labeled lactose and sucrose in rats, 6.2+/-2.7 and 7.6+/-2.4%, respectively, was oxidized to (14)CO(2) in 24 hours; 62.1+/-13.5 and 68.4+/-10.8% of the respective disaccharides was excreted into the urine. Conversely, after injection of (14)C-labeled maltose 54.6+/-7.0% was oxidized to (14)CO(2) and 4.8+/-3.9% excreted in the urine. The per cent of maltose oxidized to CO(2) was similar to that of glucose. In addition to small intestinal mucosa, homogenates of rat kidney, brain, and liver as well as serum were found to have measurable maltase activities. The role of these tissue maltases in the metabolism of circulating maltose and maltosyloligosaccharides is discussed.
ISSN:0021-9738
DOI:10.1172/JCI105552