Adiponectin and interleukin-6, but not adipose tissue, are associated with worse neurocognitive function in HIV-infected men

Generalized obesity has been associated with cognitive decline, a process potentially mediated by adipocytokines. The effects of regional adipose tissue (AT) on cognition, however, are not well understood. We explored cross-sectional relationships between regional AT, adipocytokines, inflammatory ma...

Full description

Saved in:
Bibliographic Details
Published in:Antiviral therapy 2015-01, Vol.20 (2), p.235-244
Main Authors: Lake, Jordan E, Vo, Quynh T, Jacobson, Lisa P, Sacktor, Ned, Miller, Eric N, Post, Wendy S, Becker, James T, Palella, Jr, Frank J, Ragin, Ann, Martin, Eileen, Munro, Cynthia A, Brown, Todd T
Format: Article
Language:English
Subjects:
Adiponectin - blood
Adipose Tissue - pathology
Adipose Tissue - virology
Age Factors
Anti-HIV Agents - therapeutic use
Antiretroviral Therapy, Highly Active
Biomarkers - blood
C-Reactive Protein - metabolism
Cognitive Dysfunction - complications
Cognitive Dysfunction - drug therapy
Cognitive Dysfunction - psychology
Cognitive Dysfunction - virology
Cohort Studies
Disease Progression
Educational Status
Executive Function
HIV Infections - complications
HIV Infections - drug therapy
HIV Infections - psychology
HIV Infections - virology
HIV-1 - drug effects
HIV-1 - physiology
Humans
Interleukin-6 - blood
Lentivirus
Leptin - blood
Male
Middle Aged
Multivariate Analysis
Neuropsychological Tests
Obesity - complications
Obesity - drug therapy
Obesity - psychology
Obesity - virology
Psychomotor Performance
Retroviridae
RNA, Viral - antagonists & inhibitors
RNA, Viral - blood
Viral Load - drug effects
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Generalized obesity has been associated with cognitive decline, a process potentially mediated by adipocytokines. The effects of regional adipose tissue (AT) on cognition, however, are not well understood. We explored cross-sectional relationships between regional AT, adipocytokines, inflammatory markers and neuropsychological (NP) test scores among HIV+ and HIV- men enrolled in the Multicenter AIDS Cohort Study. Visceral, subcutaneous abdominal and subcutaneous thigh AT areas were quantified by computed tomography (CT). NP tests (Trail Making Test parts A and B, and Symbol-Digit Modalities) obtained within 2 years of CT screened for psychomotor speed and executive function. Adiponectin, leptin, interleukin-6 (IL-6) and high-sensitivity C-reactive protein (hs-CRP) were measured. Of 509 HIV+ and 271 HIV- participants, HIV+ men (98% on antiretroviral therapy, 81% HIV-1 RNA
ISSN:1359-6535
2040-2058
DOI:10.3851/IMP2952