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Premature progesterone rise at human chorionic gonadotropin triggering day has no correlation with intracytoplasmic sperm injection outcome
Background: Premature luteinization during in vitro fertilization was commonly happened before the introduction of GnRh analogues. High level of unwanted progesterone is associated with adverse pregnancy outcome and is thought to be induced by inappropriate LH elevation. Objective: To evaluate the p...
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| Published in: | International journal of reproductive biomedicine (Yazd, Iran) Iran), 2015-02, Vol.13 (2), p.79-84 |
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| container_title | International journal of reproductive biomedicine (Yazd, Iran) |
| container_volume | 13 |
| creator | Saharkhiz, Nasrin Salehpour, Saghar Tavasoli, Mahboobeh Aghighi, Ali |
| description | Background: Premature luteinization during in vitro fertilization was
commonly happened before the introduction of GnRh analogues. High level
of unwanted progesterone is associated with adverse pregnancy outcome
and is thought to be induced by inappropriate LH elevation. Objective:
To evaluate the progesterone level on the day of Human Chorionic
Gonadotropin (HCG) triggering in GnRh agonist and antagonist protocols,
and its correlation with clinical pregnancy rate and miscarriage rate.
Materials and Methods: One hundred and seven women underwent
intracytoplasmic sperm injection with long agonist protocol (n=46) or
antagonist protocol (n=61). Blood sample was obtained from each patient
for progesterone level measurement in HCG administration day, then
patients were divided into two groups according to their serum
progesterone levels on the HCG triggering day: progesterone level |
| format | article |
| fullrecord | <record><control><sourceid>proquest_pubme</sourceid><recordid>TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_4426144</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>3624953701</sourcerecordid><originalsourceid>FETCH-LOGICAL-b333t-bea15f0ba2086e5b905e2c1cc5b3c0f700580389921c24b0b19f3fc7f180afa23</originalsourceid><addsrcrecordid>eNpdkc1q3TAQhU1paG7SvkIRdNONg35s2d4USmiaQKBdNGsz1h3buliSO5Jb7jP0pas0P7QdBANHnw5nRi-KnawaXaqmkS-LndAtL3Wl1GlxFuOBcy20VK-KU1l396V3xa-vhA7SRshWChPGhBQ8MrIRGSQ2bw48M3MgG7w1bAoe9iFRWK1niew0IVk_sT0c2QyR-cBMIMIFUn7Afto0M-sTgTmmsC4QXTaJK5LL8gHNHypsyQSHr4uTEZaIbx77eXF39enb5XV5--XzzeXH23JQSqVyQBD1yAeQvNVYDx2vURphTD0ow8eG87rlqu06KYysBj6IblSjaUbRchhBqvPiw4Pvug0O9wbv8y39StYBHfsAtv_3xtu5n8KPvqqkFlWVDd4_GlD4vuWd9c5Gg8sCHsMW-7x32bat0iKj7_5DD2Ejn8fLlFa15LLTmXr7d6LnKE__lIGLB2CwYbEenwlDFvonkVw-ouZCqN80i6YP</addsrcrecordid><sourcetype>Open Access Repository</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>1663520296</pqid></control><display><type>article</type><title>Premature progesterone rise at human chorionic gonadotropin triggering day has no correlation with intracytoplasmic sperm injection outcome</title><source>Open Access: PubMed Central</source><source>Publicly Available Content Database</source><creator>Saharkhiz, Nasrin ; Salehpour, Saghar ; Tavasoli, Mahboobeh ; Aghighi, Ali</creator><creatorcontrib>Saharkhiz, Nasrin ; Salehpour, Saghar ; Tavasoli, Mahboobeh ; Aghighi, Ali</creatorcontrib><description>Background: Premature luteinization during in vitro fertilization was
commonly happened before the introduction of GnRh analogues. High level
of unwanted progesterone is associated with adverse pregnancy outcome
and is thought to be induced by inappropriate LH elevation. Objective:
To evaluate the progesterone level on the day of Human Chorionic
Gonadotropin (HCG) triggering in GnRh agonist and antagonist protocols,
and its correlation with clinical pregnancy rate and miscarriage rate.
Materials and Methods: One hundred and seven women underwent
intracytoplasmic sperm injection with long agonist protocol (n=46) or
antagonist protocol (n=61). Blood sample was obtained from each patient
for progesterone level measurement in HCG administration day, then
patients were divided into two groups according to their serum
progesterone levels on the HCG triggering day: progesterone level
<1.2 ng/ml, and progesterone level ≥1.2 ng/ml. Clinical
pregnancy and miscarriage rates were evaluated as main outcomes and
biochemical pregnancy rate and implantation rate were considered as
secondary outcomes. Results: The increased prevalence rate of premature
progesterone (progesterone level ≥1.2 ng/ml) in total patients
was 13.1% (14/107) and in long agonist protocol group and antagonist
protocol group was 15.2% (7/46) and 11.5% (7/61) respectively.
Premature progesterone rise had no significant correlation with
clinical pregnancy rate in total patients (p=0.174), agonist protocol
(p=0.545), and antagonist protocol (p=0.129). Also premature
progesterone rise had no significant association with miscarriage rate
in total patients (p=0.077), agonist protocol group (p=0.383) and
antagonist protocol group (p=0.087). Conclusion: A significant rise in
progesterone levels at the time of HCG triggering doesn't lead to
decrease in pregnancy rate and implantation rate and increase in
miscarriage rate.</description><identifier>ISSN: 1680-6433</identifier><identifier>ISSN: 2476-4108</identifier><identifier>EISSN: 2476-3772</identifier><identifier>EISSN: 2008-2177</identifier><identifier>PMID: 25999996</identifier><language>eng</language><publisher>Iran: Research and Clinical Center for Infertility, Shahid Sadoughi University of Medical Sciences of Yazd</publisher><subject>GnRh agonist ; GnRh antagonist ; HCG triggering ; Intracytoplasmic sperm injection ; Original ; Progesterone rise</subject><ispartof>International journal of reproductive biomedicine (Yazd, Iran), 2015-02, Vol.13 (2), p.79-84</ispartof><rights>Copyright 2015 - Iranian Journal of Reproductive Medicine</rights><rights>Copyright Yazd Shahid Sadoughi University of Medical Sciences, Research and Clinical Center for Infertility Feb 2015</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.proquest.com/docview/1663520296/fulltextPDF?pq-origsite=primo$$EPDF$$P50$$Gproquest$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.proquest.com/docview/1663520296?pq-origsite=primo$$EHTML$$P50$$Gproquest$$Hfree_for_read</linktohtml><link.rule.ids>230,314,724,777,781,882,25734,36993,44571,53772,53774,74875</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/25999996$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Saharkhiz, Nasrin</creatorcontrib><creatorcontrib>Salehpour, Saghar</creatorcontrib><creatorcontrib>Tavasoli, Mahboobeh</creatorcontrib><creatorcontrib>Aghighi, Ali</creatorcontrib><title>Premature progesterone rise at human chorionic gonadotropin triggering day has no correlation with intracytoplasmic sperm injection outcome</title><title>International journal of reproductive biomedicine (Yazd, Iran)</title><addtitle>Iran J Reprod Med</addtitle><description>Background: Premature luteinization during in vitro fertilization was
commonly happened before the introduction of GnRh analogues. High level
of unwanted progesterone is associated with adverse pregnancy outcome
and is thought to be induced by inappropriate LH elevation. Objective:
To evaluate the progesterone level on the day of Human Chorionic
Gonadotropin (HCG) triggering in GnRh agonist and antagonist protocols,
and its correlation with clinical pregnancy rate and miscarriage rate.
Materials and Methods: One hundred and seven women underwent
intracytoplasmic sperm injection with long agonist protocol (n=46) or
antagonist protocol (n=61). Blood sample was obtained from each patient
for progesterone level measurement in HCG administration day, then
patients were divided into two groups according to their serum
progesterone levels on the HCG triggering day: progesterone level
<1.2 ng/ml, and progesterone level ≥1.2 ng/ml. Clinical
pregnancy and miscarriage rates were evaluated as main outcomes and
biochemical pregnancy rate and implantation rate were considered as
secondary outcomes. Results: The increased prevalence rate of premature
progesterone (progesterone level ≥1.2 ng/ml) in total patients
was 13.1% (14/107) and in long agonist protocol group and antagonist
protocol group was 15.2% (7/46) and 11.5% (7/61) respectively.
Premature progesterone rise had no significant correlation with
clinical pregnancy rate in total patients (p=0.174), agonist protocol
(p=0.545), and antagonist protocol (p=0.129). Also premature
progesterone rise had no significant association with miscarriage rate
in total patients (p=0.077), agonist protocol group (p=0.383) and
antagonist protocol group (p=0.087). Conclusion: A significant rise in
progesterone levels at the time of HCG triggering doesn't lead to
decrease in pregnancy rate and implantation rate and increase in
miscarriage rate.</description><subject>GnRh agonist</subject><subject>GnRh antagonist</subject><subject>HCG triggering</subject><subject>Intracytoplasmic sperm injection</subject><subject>Original</subject><subject>Progesterone rise</subject><issn>1680-6433</issn><issn>2476-4108</issn><issn>2476-3772</issn><issn>2008-2177</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2015</creationdate><recordtype>article</recordtype><sourceid>PIMPY</sourceid><recordid>eNpdkc1q3TAQhU1paG7SvkIRdNONg35s2d4USmiaQKBdNGsz1h3buliSO5Jb7jP0pas0P7QdBANHnw5nRi-KnawaXaqmkS-LndAtL3Wl1GlxFuOBcy20VK-KU1l396V3xa-vhA7SRshWChPGhBQ8MrIRGSQ2bw48M3MgG7w1bAoe9iFRWK1niew0IVk_sT0c2QyR-cBMIMIFUn7Afto0M-sTgTmmsC4QXTaJK5LL8gHNHypsyQSHr4uTEZaIbx77eXF39enb5XV5--XzzeXH23JQSqVyQBD1yAeQvNVYDx2vURphTD0ow8eG87rlqu06KYysBj6IblSjaUbRchhBqvPiw4Pvug0O9wbv8y39StYBHfsAtv_3xtu5n8KPvqqkFlWVDd4_GlD4vuWd9c5Gg8sCHsMW-7x32bat0iKj7_5DD2Ejn8fLlFa15LLTmXr7d6LnKE__lIGLB2CwYbEenwlDFvonkVw-ouZCqN80i6YP</recordid><startdate>20150201</startdate><enddate>20150201</enddate><creator>Saharkhiz, Nasrin</creator><creator>Salehpour, Saghar</creator><creator>Tavasoli, Mahboobeh</creator><creator>Aghighi, Ali</creator><general>Research and Clinical Center for Infertility, Shahid Sadoughi University of Medical Sciences of Yazd</general><general>Yazd Shahid Sadoughi University of Medical Sciences, Research and Clinical Center for Infertility</general><general>Research and Clinical Center for Infertility</general><scope>RBI</scope><scope>NPM</scope><scope>3V.</scope><scope>7X7</scope><scope>7XB</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>8G5</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BENPR</scope><scope>CCPQU</scope><scope>CWDGH</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>GUQSH</scope><scope>K9.</scope><scope>M0S</scope><scope>M2O</scope><scope>MBDVC</scope><scope>PIMPY</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>Q9U</scope><scope>7X8</scope><scope>5PM</scope></search><sort><creationdate>20150201</creationdate><title>Premature progesterone rise at human chorionic gonadotropin triggering day has no correlation with intracytoplasmic sperm injection outcome</title><author>Saharkhiz, Nasrin ; Salehpour, Saghar ; Tavasoli, Mahboobeh ; Aghighi, Ali</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-b333t-bea15f0ba2086e5b905e2c1cc5b3c0f700580389921c24b0b19f3fc7f180afa23</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2015</creationdate><topic>GnRh agonist</topic><topic>GnRh antagonist</topic><topic>HCG triggering</topic><topic>Intracytoplasmic sperm injection</topic><topic>Original</topic><topic>Progesterone rise</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Saharkhiz, Nasrin</creatorcontrib><creatorcontrib>Salehpour, Saghar</creatorcontrib><creatorcontrib>Tavasoli, Mahboobeh</creatorcontrib><creatorcontrib>Aghighi, Ali</creatorcontrib><collection>Bioline International</collection><collection>PubMed</collection><collection>ProQuest Central (Corporate)</collection><collection>ProQuest Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>Research Library (Alumni Edition)</collection><collection>ProQuest Central (Alumni)</collection><collection>ProQuest Central</collection><collection>ProQuest Central Essentials</collection><collection>AUTh Library subscriptions: ProQuest Central</collection><collection>ProQuest One Community College</collection><collection>Middle East & Africa Database</collection><collection>ProQuest Central Korea</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>Research Library Prep</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>ProQuest Research Library</collection><collection>Research Library (Corporate)</collection><collection>Publicly Available Content Database</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central Basic</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>International journal of reproductive biomedicine (Yazd, Iran)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Saharkhiz, Nasrin</au><au>Salehpour, Saghar</au><au>Tavasoli, Mahboobeh</au><au>Aghighi, Ali</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Premature progesterone rise at human chorionic gonadotropin triggering day has no correlation with intracytoplasmic sperm injection outcome</atitle><jtitle>International journal of reproductive biomedicine (Yazd, Iran)</jtitle><addtitle>Iran J Reprod Med</addtitle><date>2015-02-01</date><risdate>2015</risdate><volume>13</volume><issue>2</issue><spage>79</spage><epage>84</epage><pages>79-84</pages><issn>1680-6433</issn><issn>2476-4108</issn><eissn>2476-3772</eissn><eissn>2008-2177</eissn><abstract>Background: Premature luteinization during in vitro fertilization was
commonly happened before the introduction of GnRh analogues. High level
of unwanted progesterone is associated with adverse pregnancy outcome
and is thought to be induced by inappropriate LH elevation. Objective:
To evaluate the progesterone level on the day of Human Chorionic
Gonadotropin (HCG) triggering in GnRh agonist and antagonist protocols,
and its correlation with clinical pregnancy rate and miscarriage rate.
Materials and Methods: One hundred and seven women underwent
intracytoplasmic sperm injection with long agonist protocol (n=46) or
antagonist protocol (n=61). Blood sample was obtained from each patient
for progesterone level measurement in HCG administration day, then
patients were divided into two groups according to their serum
progesterone levels on the HCG triggering day: progesterone level
<1.2 ng/ml, and progesterone level ≥1.2 ng/ml. Clinical
pregnancy and miscarriage rates were evaluated as main outcomes and
biochemical pregnancy rate and implantation rate were considered as
secondary outcomes. Results: The increased prevalence rate of premature
progesterone (progesterone level ≥1.2 ng/ml) in total patients
was 13.1% (14/107) and in long agonist protocol group and antagonist
protocol group was 15.2% (7/46) and 11.5% (7/61) respectively.
Premature progesterone rise had no significant correlation with
clinical pregnancy rate in total patients (p=0.174), agonist protocol
(p=0.545), and antagonist protocol (p=0.129). Also premature
progesterone rise had no significant association with miscarriage rate
in total patients (p=0.077), agonist protocol group (p=0.383) and
antagonist protocol group (p=0.087). Conclusion: A significant rise in
progesterone levels at the time of HCG triggering doesn't lead to
decrease in pregnancy rate and implantation rate and increase in
miscarriage rate.</abstract><cop>Iran</cop><pub>Research and Clinical Center for Infertility, Shahid Sadoughi University of Medical Sciences of Yazd</pub><pmid>25999996</pmid><tpages>6</tpages><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 1680-6433 |
| ispartof | International journal of reproductive biomedicine (Yazd, Iran), 2015-02, Vol.13 (2), p.79-84 |
| issn | 1680-6433 2476-4108 2476-3772 2008-2177 |
| language | eng |
| recordid | cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_4426144 |
| source | Open Access: PubMed Central; Publicly Available Content Database |
| subjects | GnRh agonist GnRh antagonist HCG triggering Intracytoplasmic sperm injection Original Progesterone rise |
| title | Premature progesterone rise at human chorionic gonadotropin triggering day has no correlation with intracytoplasmic sperm injection outcome |
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