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Systemic oxidative stress could predict assisted reproductive technique outcome
Purpose Previous studies have indicated that OxS (oxidative stress) may appear as a possible reason for poor ART outcome. Our aim was to study OxS levels in both partners of couples seeking Assisted reproduction Technology (ART). Methods Altogether 79 couples were recruited. Oxidative DNA damage (8-...
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| Published in: | Journal of assisted reproduction and genetics 2015-05, Vol.32 (5), p.699-704 |
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| Main Authors: | , , , , , , , , |
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| cites | cdi_FETCH-LOGICAL-c540t-45675ce85cb02814e5a591558f1dacfe257d6d9885591db6f83da13dcb6920a33 |
| container_end_page | 704 |
| container_issue | 5 |
| container_start_page | 699 |
| container_title | Journal of assisted reproduction and genetics |
| container_volume | 32 |
| creator | Ahelik, A. Mändar, R. Korrovits, P. Karits, P. Talving, E. Rosenstein, K. Jaagura, M. Salumets, A. Kullisaar, T. |
| description | Purpose
Previous studies have indicated that OxS (oxidative stress) may appear as a possible reason for poor ART outcome. Our aim was to study OxS levels in both partners of couples seeking Assisted reproduction Technology (ART).
Methods
Altogether 79 couples were recruited. Oxidative DNA damage (8-OHdG) and lipid peroxidation (8-EPI) were measured, and clinical background and ART outcomes were recorded.
Results
Both OxS markers accurately reflected clincal conditions with prominent negative effects attributable to genital tract infections, endometriosis, uterine myoma and smoking. Furthermore, the level of OxS was also affected by partner’s state of health. The highest 8-EPI levels were detected in both partners when biochemically detectable pregnancies did not develop into clinically detectable pregnancies (in women, 97,8 ± 16,7 vs 72.9 ± 22,9,
p
= 0.007; in men, 89.6 ± 20,4 vs 72,1 ± 22,6,
p
= 0.049).
Conclusions
To conclude, high grade systemix OxS in both partners may negatively affect the maintenance and outcome of pregnancy. Applying the detection of OxS in ART patients may select patients with higher success rate and/or those who require antioxidant therapy. This would lead to improvement of ART outcome as well as natural fertility. |
| doi_str_mv | 10.1007/s10815-015-0466-6 |
| format | article |
| fullrecord | <record><control><sourceid>proquest_pubme</sourceid><recordid>TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_4429443</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>3683370561</sourcerecordid><originalsourceid>FETCH-LOGICAL-c540t-45675ce85cb02814e5a591558f1dacfe257d6d9885591db6f83da13dcb6920a33</originalsourceid><addsrcrecordid>eNp1kUtLJTEQhYMovn_AbIYGN7NpzbvTm4FBxgcILtR1yE2qNdLduZOkL_rvTXtVHMFFkZDz1UkVB6EfBB8TjJuTRLAiosZzcSlruYF2iWhY3TCGN8sdCzUragftpfSIMW4VZdtohwpFmBRqF13fPKcMg7dVePLOZL-CKuUIKVU2TL2rlhGct7kyKflCuirCMgY32Vc0g30Y_b8JqjBlGwY4QFud6RMcvp376O7s7-3pRX11fX55-ueqtoLjXHMhG2FBCbvAVBEOwoiWCKE64oztgIrGSdcqJcqzW8hOMWcIc3YhW4oNY_vo99p3OS0GcBbGHE2vl9EPJj7rYLz-Xxn9g74PK805bTmfDX69GcRQ5k9ZDz5Z6HszQpiSJlIRKiltZvToC_oYpjiW9WYKS0k5bwtF1pSNIaUI3ccwBOs5Lr2OS-O5Slxalp6fn7f46HjPpwB0DaQijfcQP339resLEnahzg</addsrcrecordid><sourcetype>Open Access Repository</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>1680662449</pqid></control><display><type>article</type><title>Systemic oxidative stress could predict assisted reproductive technique outcome</title><source>PubMed Central Free</source><source>Springer Link</source><creator>Ahelik, A. ; Mändar, R. ; Korrovits, P. ; Karits, P. ; Talving, E. ; Rosenstein, K. ; Jaagura, M. ; Salumets, A. ; Kullisaar, T.</creator><creatorcontrib>Ahelik, A. ; Mändar, R. ; Korrovits, P. ; Karits, P. ; Talving, E. ; Rosenstein, K. ; Jaagura, M. ; Salumets, A. ; Kullisaar, T.</creatorcontrib><description>Purpose
Previous studies have indicated that OxS (oxidative stress) may appear as a possible reason for poor ART outcome. Our aim was to study OxS levels in both partners of couples seeking Assisted reproduction Technology (ART).
Methods
Altogether 79 couples were recruited. Oxidative DNA damage (8-OHdG) and lipid peroxidation (8-EPI) were measured, and clinical background and ART outcomes were recorded.
Results
Both OxS markers accurately reflected clincal conditions with prominent negative effects attributable to genital tract infections, endometriosis, uterine myoma and smoking. Furthermore, the level of OxS was also affected by partner’s state of health. The highest 8-EPI levels were detected in both partners when biochemically detectable pregnancies did not develop into clinically detectable pregnancies (in women, 97,8 ± 16,7 vs 72.9 ± 22,9,
p
= 0.007; in men, 89.6 ± 20,4 vs 72,1 ± 22,6,
p
= 0.049).
Conclusions
To conclude, high grade systemix OxS in both partners may negatively affect the maintenance and outcome of pregnancy. Applying the detection of OxS in ART patients may select patients with higher success rate and/or those who require antioxidant therapy. This would lead to improvement of ART outcome as well as natural fertility.</description><identifier>ISSN: 1058-0468</identifier><identifier>EISSN: 1573-7330</identifier><identifier>DOI: 10.1007/s10815-015-0466-6</identifier><identifier>PMID: 25813658</identifier><language>eng</language><publisher>New York: Springer US</publisher><subject>Adult ; Assisted Reproduction Technologies ; Biomarkers - analysis ; Couples ; Dinoprost - analogs & derivatives ; Dinoprost - analysis ; DNA Damage ; Embryos ; Female ; Fertility ; Fertilization in Vitro - methods ; Gynecology ; Human Genetics ; Humans ; In vitro fertilization ; Infections ; Infertility ; Infertility - diagnosis ; Infertility - etiology ; Infertility - metabolism ; Lipid Peroxidation ; Lipids ; Male ; Medicine ; Medicine & Public Health ; Oxidative Stress ; Pregnancy ; Pregnancy Outcome ; Reproductive Medicine ; Reproductive Techniques, Assisted - adverse effects ; Semen Analysis ; Sperm ; Urinalysis ; Urine ; Vagina</subject><ispartof>Journal of assisted reproduction and genetics, 2015-05, Vol.32 (5), p.699-704</ispartof><rights>Springer Science+Business Media New York 2015</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c540t-45675ce85cb02814e5a591558f1dacfe257d6d9885591db6f83da13dcb6920a33</citedby><cites>FETCH-LOGICAL-c540t-45675ce85cb02814e5a591558f1dacfe257d6d9885591db6f83da13dcb6920a33</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC4429443/pdf/$$EPDF$$P50$$Gpubmedcentral$$H</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC4429443/$$EHTML$$P50$$Gpubmedcentral$$H</linktohtml><link.rule.ids>230,314,727,780,784,885,27924,27925,53791,53793</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/25813658$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Ahelik, A.</creatorcontrib><creatorcontrib>Mändar, R.</creatorcontrib><creatorcontrib>Korrovits, P.</creatorcontrib><creatorcontrib>Karits, P.</creatorcontrib><creatorcontrib>Talving, E.</creatorcontrib><creatorcontrib>Rosenstein, K.</creatorcontrib><creatorcontrib>Jaagura, M.</creatorcontrib><creatorcontrib>Salumets, A.</creatorcontrib><creatorcontrib>Kullisaar, T.</creatorcontrib><title>Systemic oxidative stress could predict assisted reproductive technique outcome</title><title>Journal of assisted reproduction and genetics</title><addtitle>J Assist Reprod Genet</addtitle><addtitle>J Assist Reprod Genet</addtitle><description>Purpose
Previous studies have indicated that OxS (oxidative stress) may appear as a possible reason for poor ART outcome. Our aim was to study OxS levels in both partners of couples seeking Assisted reproduction Technology (ART).
Methods
Altogether 79 couples were recruited. Oxidative DNA damage (8-OHdG) and lipid peroxidation (8-EPI) were measured, and clinical background and ART outcomes were recorded.
Results
Both OxS markers accurately reflected clincal conditions with prominent negative effects attributable to genital tract infections, endometriosis, uterine myoma and smoking. Furthermore, the level of OxS was also affected by partner’s state of health. The highest 8-EPI levels were detected in both partners when biochemically detectable pregnancies did not develop into clinically detectable pregnancies (in women, 97,8 ± 16,7 vs 72.9 ± 22,9,
p
= 0.007; in men, 89.6 ± 20,4 vs 72,1 ± 22,6,
p
= 0.049).
Conclusions
To conclude, high grade systemix OxS in both partners may negatively affect the maintenance and outcome of pregnancy. Applying the detection of OxS in ART patients may select patients with higher success rate and/or those who require antioxidant therapy. This would lead to improvement of ART outcome as well as natural fertility.</description><subject>Adult</subject><subject>Assisted Reproduction Technologies</subject><subject>Biomarkers - analysis</subject><subject>Couples</subject><subject>Dinoprost - analogs & derivatives</subject><subject>Dinoprost - analysis</subject><subject>DNA Damage</subject><subject>Embryos</subject><subject>Female</subject><subject>Fertility</subject><subject>Fertilization in Vitro - methods</subject><subject>Gynecology</subject><subject>Human Genetics</subject><subject>Humans</subject><subject>In vitro fertilization</subject><subject>Infections</subject><subject>Infertility</subject><subject>Infertility - diagnosis</subject><subject>Infertility - etiology</subject><subject>Infertility - metabolism</subject><subject>Lipid Peroxidation</subject><subject>Lipids</subject><subject>Male</subject><subject>Medicine</subject><subject>Medicine & Public Health</subject><subject>Oxidative Stress</subject><subject>Pregnancy</subject><subject>Pregnancy Outcome</subject><subject>Reproductive Medicine</subject><subject>Reproductive Techniques, Assisted - adverse effects</subject><subject>Semen Analysis</subject><subject>Sperm</subject><subject>Urinalysis</subject><subject>Urine</subject><subject>Vagina</subject><issn>1058-0468</issn><issn>1573-7330</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2015</creationdate><recordtype>article</recordtype><recordid>eNp1kUtLJTEQhYMovn_AbIYGN7NpzbvTm4FBxgcILtR1yE2qNdLduZOkL_rvTXtVHMFFkZDz1UkVB6EfBB8TjJuTRLAiosZzcSlruYF2iWhY3TCGN8sdCzUragftpfSIMW4VZdtohwpFmBRqF13fPKcMg7dVePLOZL-CKuUIKVU2TL2rlhGct7kyKflCuirCMgY32Vc0g30Y_b8JqjBlGwY4QFud6RMcvp376O7s7-3pRX11fX55-ueqtoLjXHMhG2FBCbvAVBEOwoiWCKE64oztgIrGSdcqJcqzW8hOMWcIc3YhW4oNY_vo99p3OS0GcBbGHE2vl9EPJj7rYLz-Xxn9g74PK805bTmfDX69GcRQ5k9ZDz5Z6HszQpiSJlIRKiltZvToC_oYpjiW9WYKS0k5bwtF1pSNIaUI3ccwBOs5Lr2OS-O5Slxalp6fn7f46HjPpwB0DaQijfcQP339resLEnahzg</recordid><startdate>20150501</startdate><enddate>20150501</enddate><creator>Ahelik, A.</creator><creator>Mändar, R.</creator><creator>Korrovits, P.</creator><creator>Karits, P.</creator><creator>Talving, E.</creator><creator>Rosenstein, K.</creator><creator>Jaagura, M.</creator><creator>Salumets, A.</creator><creator>Kullisaar, T.</creator><general>Springer US</general><general>Springer Nature B.V</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8AO</scope><scope>8C1</scope><scope>8FD</scope><scope>8FE</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BHPHI</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FR3</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>HCIFZ</scope><scope>K9.</scope><scope>LK8</scope><scope>M0S</scope><scope>M1P</scope><scope>M7P</scope><scope>P64</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>RC3</scope><scope>7X8</scope><scope>5PM</scope></search><sort><creationdate>20150501</creationdate><title>Systemic oxidative stress could predict assisted reproductive technique outcome</title><author>Ahelik, A. ; Mändar, R. ; Korrovits, P. ; Karits, P. ; Talving, E. ; Rosenstein, K. ; Jaagura, M. ; Salumets, A. ; Kullisaar, T.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c540t-45675ce85cb02814e5a591558f1dacfe257d6d9885591db6f83da13dcb6920a33</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2015</creationdate><topic>Adult</topic><topic>Assisted Reproduction Technologies</topic><topic>Biomarkers - analysis</topic><topic>Couples</topic><topic>Dinoprost - analogs & derivatives</topic><topic>Dinoprost - analysis</topic><topic>DNA Damage</topic><topic>Embryos</topic><topic>Female</topic><topic>Fertility</topic><topic>Fertilization in Vitro - methods</topic><topic>Gynecology</topic><topic>Human Genetics</topic><topic>Humans</topic><topic>In vitro fertilization</topic><topic>Infections</topic><topic>Infertility</topic><topic>Infertility - diagnosis</topic><topic>Infertility - etiology</topic><topic>Infertility - metabolism</topic><topic>Lipid Peroxidation</topic><topic>Lipids</topic><topic>Male</topic><topic>Medicine</topic><topic>Medicine & Public Health</topic><topic>Oxidative Stress</topic><topic>Pregnancy</topic><topic>Pregnancy Outcome</topic><topic>Reproductive Medicine</topic><topic>Reproductive Techniques, Assisted - adverse effects</topic><topic>Semen Analysis</topic><topic>Sperm</topic><topic>Urinalysis</topic><topic>Urine</topic><topic>Vagina</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Ahelik, A.</creatorcontrib><creatorcontrib>Mändar, R.</creatorcontrib><creatorcontrib>Korrovits, P.</creatorcontrib><creatorcontrib>Karits, P.</creatorcontrib><creatorcontrib>Talving, E.</creatorcontrib><creatorcontrib>Rosenstein, K.</creatorcontrib><creatorcontrib>Jaagura, M.</creatorcontrib><creatorcontrib>Salumets, A.</creatorcontrib><creatorcontrib>Kullisaar, T.</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>ProQuest Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>ProQuest Pharma Collection</collection><collection>Public Health Database</collection><collection>Technology Research Database</collection><collection>ProQuest SciTech Collection</collection><collection>ProQuest Natural Science Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni)</collection><collection>ProQuest Central</collection><collection>ProQuest Central Essentials</collection><collection>Biological Science Collection</collection><collection>AUTh Library subscriptions: ProQuest Central</collection><collection>ProQuest Natural Science Collection</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central</collection><collection>Engineering Research Database</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>SciTech Premium Collection (Proquest) (PQ_SDU_P3)</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Biological Sciences</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>PML(ProQuest Medical Library)</collection><collection>ProQuest Biological Science Journals</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>Genetics Abstracts</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Journal of assisted reproduction and genetics</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Ahelik, A.</au><au>Mändar, R.</au><au>Korrovits, P.</au><au>Karits, P.</au><au>Talving, E.</au><au>Rosenstein, K.</au><au>Jaagura, M.</au><au>Salumets, A.</au><au>Kullisaar, T.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Systemic oxidative stress could predict assisted reproductive technique outcome</atitle><jtitle>Journal of assisted reproduction and genetics</jtitle><stitle>J Assist Reprod Genet</stitle><addtitle>J Assist Reprod Genet</addtitle><date>2015-05-01</date><risdate>2015</risdate><volume>32</volume><issue>5</issue><spage>699</spage><epage>704</epage><pages>699-704</pages><issn>1058-0468</issn><eissn>1573-7330</eissn><abstract>Purpose
Previous studies have indicated that OxS (oxidative stress) may appear as a possible reason for poor ART outcome. Our aim was to study OxS levels in both partners of couples seeking Assisted reproduction Technology (ART).
Methods
Altogether 79 couples were recruited. Oxidative DNA damage (8-OHdG) and lipid peroxidation (8-EPI) were measured, and clinical background and ART outcomes were recorded.
Results
Both OxS markers accurately reflected clincal conditions with prominent negative effects attributable to genital tract infections, endometriosis, uterine myoma and smoking. Furthermore, the level of OxS was also affected by partner’s state of health. The highest 8-EPI levels were detected in both partners when biochemically detectable pregnancies did not develop into clinically detectable pregnancies (in women, 97,8 ± 16,7 vs 72.9 ± 22,9,
p
= 0.007; in men, 89.6 ± 20,4 vs 72,1 ± 22,6,
p
= 0.049).
Conclusions
To conclude, high grade systemix OxS in both partners may negatively affect the maintenance and outcome of pregnancy. Applying the detection of OxS in ART patients may select patients with higher success rate and/or those who require antioxidant therapy. This would lead to improvement of ART outcome as well as natural fertility.</abstract><cop>New York</cop><pub>Springer US</pub><pmid>25813658</pmid><doi>10.1007/s10815-015-0466-6</doi><tpages>6</tpages><oa>free_for_read</oa></addata></record> |
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| ispartof | Journal of assisted reproduction and genetics, 2015-05, Vol.32 (5), p.699-704 |
| issn | 1058-0468 1573-7330 |
| language | eng |
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| source | PubMed Central Free; Springer Link |
| subjects | Adult Assisted Reproduction Technologies Biomarkers - analysis Couples Dinoprost - analogs & derivatives Dinoprost - analysis DNA Damage Embryos Female Fertility Fertilization in Vitro - methods Gynecology Human Genetics Humans In vitro fertilization Infections Infertility Infertility - diagnosis Infertility - etiology Infertility - metabolism Lipid Peroxidation Lipids Male Medicine Medicine & Public Health Oxidative Stress Pregnancy Pregnancy Outcome Reproductive Medicine Reproductive Techniques, Assisted - adverse effects Semen Analysis Sperm Urinalysis Urine Vagina |
| title | Systemic oxidative stress could predict assisted reproductive technique outcome |
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