Trends in susceptibility of Escherichia coli from intra-abdominal infections to ertapenem and comparators in the United States according to data from the SMART program, 2009 to 2013

Antimicrobial resistance in Enterobacteriaceae, including resistance to carbapenems, is increasing worldwide. However, using U.S. Study for Monitoring Antimicrobial Resistance Trends (SMART) data for 2009 to 2013, no statistically significant decreasing susceptibility trends were found overall for E...

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Bibliographic Details
Published in:Antimicrobial agents and chemotherapy 2015-06, Vol.59 (6), p.3606-3610
Main Authors: Lob, Sibylle H, Kazmierczak, Krystyna M, Badal, Robert E, Hackel, Meredith A, Bouchillon, Samuel K, Biedenbach, Douglas J, Sahm, Daniel F
Format: Article
Language:English
Subjects:
Anti-Bacterial Agents
Anti-Bacterial Agents - pharmacology
beta-Lactamases - genetics
beta-Lactamases - metabolism
beta-Lactams
beta-Lactams - pharmacology
Escherichia coli
Escherichia coli - drug effects
Escherichia coli - enzymology
Genotype
Humans
Intraabdominal Infections
Intraabdominal Infections - microbiology
Microbial Sensitivity Tests
Susceptibility
United States
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Summary:Antimicrobial resistance in Enterobacteriaceae, including resistance to carbapenems, is increasing worldwide. However, using U.S. Study for Monitoring Antimicrobial Resistance Trends (SMART) data for 2009 to 2013, no statistically significant decreasing susceptibility trends were found overall for Escherichia coli isolates from patients with intra-abdominal infections. In the subset of isolates from community-associated infections, susceptibility to levofloxacin decreased significantly and the increasing rate of multidrug-resistant E. coli approached statistical significance. In 2013, ertapenem, imipenem, and amikacin showed the highest susceptibility rates (≥99%) and fluoroquinolones the lowest (
ISSN:0066-4804
1098-6596
DOI:10.1128/aac.05186-14