Decreases in theta and increases in high frequency activity underlie associative memory encoding

Episodic memory encoding refers to the cognitive process by which items and their associated contexts are stored in memory. To investigate changes directly attributed to the formation of explicit associations, we examined oscillatory power captured through intracranial electroencephalography (iEEG)...

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Bibliographic Details
Published in:NeuroImage (Orlando, Fla.) Fla.), 2015-07, Vol.114, p.257-263
Main Authors: Greenberg, Jeffrey A., Burke, John F., Haque, Rafi, Kahana, Michael J., Zaghloul, Kareem A.
Format: Article
Language:English
Subjects:
Adult
Association Learning - physiology
Associative memory encoding
Brain - physiology
Brain research
Brain Waves
Electroencephalography
Episodic memory
Female
Humans
iEEG
Male
Memory
Memory, Episodic
Middle Aged
Patients
Recall
Rodents
Studies
Subsequent memory effect
Theta Rhythm
Young Adult
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Summary:Episodic memory encoding refers to the cognitive process by which items and their associated contexts are stored in memory. To investigate changes directly attributed to the formation of explicit associations, we examined oscillatory power captured through intracranial electroencephalography (iEEG) as 27 neurosurgical patients receiving subdural and depth electrodes for seizure monitoring participated in a paired associates memory task. We examined low (3–8Hz) and high (45–95Hz) frequency activity, and found that the successful formation of new associations was accompanied by broad decreases in low frequency activity and a posterior to anterior progression of increases in high frequency activity in the left hemisphere. These data suggest that the observed patterns of activity may reflect the neural mechanisms underlying the formation of novel item-item associations. •Intracranial encephalography (iEEG) was used to explore associative memory encoding.•Decreases in cortical low frequency activity are linked with associative encoding.•A progression of cortical high frequency activity increases mark encoding.
ISSN:1053-8119
1095-9572
DOI:10.1016/j.neuroimage.2015.03.077