25-hydroxyvitamin D levels, vitamin D binding protein gene polymorphisms and incident coronary heart disease among whites and blacks: The ARIC study

Abstract Background In observational studies, low 25-hydroxyvitamin D (25(OH)D) has been associated with increased risk of coronary heart disease (CHD), and this association may vary by race. Racial differences in the frequency of vitamin D binding protein (DBP) single nucleotide polymorphisms (SNPs...

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Published in:Atherosclerosis 2015-07, Vol.241 (1), p.12-17
Main Authors: Michos, Erin D, Misialek, Jeffrey R, Selvin, Elizabeth, Folsom, Aaron R, Pankow, James S, Post, Wendy S, Lutsey, Pamela L
Format: Article
Language:English
Subjects:
Biomarkers - blood
Black or African American - genetics
Cardiovascular
Comorbidity
Coronary Disease - blood
Coronary Disease - ethnology
Coronary Disease - genetics
Coronary heart disease
Epidemiology
Female
Gene Frequency
Genetic Predisposition to Disease
Health Status Disparities
Humans
Incidence
Linear Models
Male
Middle Aged
Phenotype
Polymorphism, Single Nucleotide
Proportional Hazards Models
Prospective Studies
Race
Risk Factors
Time Factors
United States - epidemiology
Vitamin D
Vitamin D - analogs & derivatives
Vitamin D - blood
Vitamin D binding protein
Vitamin D Deficiency - blood
Vitamin D Deficiency - ethnology
Vitamin D-Binding Protein - genetics
White People - genetics
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Summary:Abstract Background In observational studies, low 25-hydroxyvitamin D (25(OH)D) has been associated with increased risk of coronary heart disease (CHD), and this association may vary by race. Racial differences in the frequency of vitamin D binding protein (DBP) single nucleotide polymorphisms (SNPs) might account for similar bioavailable vitamin D in blacks despite lower mean 25(OH)D. We hypothesized that the associations of low 25(OH)D with CHD risk would be stronger among whites and among persons with genotypes associated with higher DBP levels. Methods We measured 25(OH)D by mass spectroscopy in 11,945 participants in the ARIC Study (baseline 1990–1992, mean age 57 years, 59% women, 24% black). Two DBP SNPs (rs7041; rs4588) were genotyped. We used adjusted Cox proportional hazards models to examine the association of 25(OH)D with adjudicated CHD events through December 2011. Results Over a median of 20 years, there were 1230 incident CHD events. Whites in the lowest quintile of 25(OH)D (
ISSN:0021-9150
1879-1484
DOI:10.1016/j.atherosclerosis.2015.04.803