Rapid onset vasodilatation is blunted in obese humans

Aim:  Conduit artery function in obese humans is frequently assessed at rest, but very little is known about resistance artery function in response to muscle contraction. We tested the hypothesis that obese adults will exhibit reduced contraction‐induced rapid onset vasodilatation. Single and brief...

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Bibliographic Details
Published in:Acta Physiologica 2012-05, Vol.205 (1), p.103-112
Main Authors: Blain, G. M., Limberg, J. K., Mortensen, G. F., Schrage, W. G.
Format: Article
Language:English
Subjects:
Activities
Adult
Adults
Arms
Biological and medical sciences
Blood Flow Velocity
Blood Flow Velocity - physiology
Blood Pressure
Blood Pressure - physiology
Body Composition
Body Composition - physiology
Body mass
Circulatory system
exercise
Female
Fingers
Forearm
Forearm - blood supply
Fundamental and applied biological sciences. Psychology
Heart Rate
Heart Rate - physiology
Hemodynamics
Hemodynamics - physiology
Human health and pathology
Humans
hyperaemia
Life Sciences
Male
Muscle Contraction
Muscle Contraction - physiology
Muscle, Skeletal
Muscle, Skeletal - blood supply
Muscle, Skeletal - physiopathology
Muscles (contractions)
Obesity
Obesity - physiopathology
Regional Blood Flow
Regional Blood Flow - physiology
Tissues and Organs
vascular conductance
Vasodilation
Vasodilation - physiology
Vertebrates: anatomy and physiology, studies on body, several organs or systems
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Summary:Aim:  Conduit artery function in obese humans is frequently assessed at rest, but very little is known about resistance artery function in response to muscle contraction. We tested the hypothesis that obese adults will exhibit reduced contraction‐induced rapid onset vasodilatation. Single and brief forearm contractions were used to isolate the local effects of muscle contraction on the forearm vasodilatory response, independent of systemic haemodynamic and sympathetic neural influence. Methods:  We measured forearm blood flow (Doppler ultrasound), blood pressure (finger photoplethysmography) and heart rate (electrocardiogram) on a beat‐by‐beat basis in 14 obese (body mass index = 36.2 ± 1.7 kg m−2) and 14 lean (body mass index = 21.6 ± 0.7 kg m−2) young (18–40 years) adults. Percent changes from baseline in forearm vascular conductance (FVC%) were calculated in response to single, brief forearm contractions performed in random order at 15, 20, 25, 30, 40 and 50% of maximal voluntary contraction (MVC). Results:  In both groups, each single contraction evoked a significant (P 
ISSN:1748-1708
1748-1716
DOI:10.1111/j.1748-1716.2011.02370.x