Methamphetamine acutely inhibits voltage-gated calcium channels but chronically upregulates L-type channels

In neurons, calcium (Ca 2+ ) channels regulate a wide variety of functions ranging from synaptic transmission to gene expression. They also induce neuroplastic changes that alter gene expression following psychostimulant administration. Ca 2+ channel blockers have been considered as potential therap...

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Bibliographic Details
Published in:Journal of neurochemistry 2015-04, Vol.134 (1), p.56-65
Main Authors: Andres, M.A., Cooke, I.M., Bellinger, F.P., Berry, M.J., Zaporteza, M., Rueli, R.H., Barayuga, S.M., Chang, L.
Format: Article
Language:English
Online Access:Get full text
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Summary:In neurons, calcium (Ca 2+ ) channels regulate a wide variety of functions ranging from synaptic transmission to gene expression. They also induce neuroplastic changes that alter gene expression following psychostimulant administration. Ca 2+ channel blockers have been considered as potential therapeutic agents for the treatment of methamphetamine (METH) dependence because of their ability to reduce drug craving among METH users. Here, we studied the effects of METH exposure on voltage-gated Ca 2+ channels using SH-SY5Y cells as a model of dopaminergic neurons. We found that METH has different short- and long-term effects. A short-term effect involves immediate (
ISSN:0022-3042
1471-4159
DOI:10.1111/jnc.13104