Serum Cystatin C for the Diagnosis of Acute Kidney Injury in Patients Admitted in the Emergency Department

Background. Early diagnosis of acute kidney injury (AKI) at emergency department (ED) is a challenging issue. Current diagnostic criteria for AKI poorly recognize early renal dysfunction and may cause delayed diagnosis. We evaluated the use of serum cystatin C (CysC) for the early and accurate diagn...

Full description

Saved in:
Bibliographic Details
Published in:Disease markers 2015-01, Vol.2015 (2015), p.1-7
Main Authors: Di Somma, Salvatore, Hur, Mina, Cardelli, Patrizia, Gori, Chiara Serena, Salerno, Gerardo, Magrini, Laura, Bongiovanni, Cristina, Buggi, Marco
Format: Article
Language:English
Subjects:
Acute Kidney Injury - blood
Acute Kidney Injury - diagnosis
Aged
Aged, 80 and over
Biomarkers - blood
Cystatin C - blood
Emergency Service, Hospital - statistics & numerical data
Female
Glomerular Filtration Rate
Humans
Injuries
Kidneys
Male
Methods
Middle Aged
Molecular diagnostic techniques
Properties
Protease inhibitors
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Background. Early diagnosis of acute kidney injury (AKI) at emergency department (ED) is a challenging issue. Current diagnostic criteria for AKI poorly recognize early renal dysfunction and may cause delayed diagnosis. We evaluated the use of serum cystatin C (CysC) for the early and accurate diagnosis of AKI in patients hospitalized from the ED. Methods. In a total of 198 patients (105 males and 93 females), serum CysC, serum creatinine (sCr), and estimated glomerular filtration rate (eGFR) were calculated at 0, 6, 12, 24, 48, and 72 hours after presentation to the ED. We compared two groups according to the presence or absence of AKI. Results. Serial assessment of CysC, sCr, and eGFR was not a strong, reliable tool to distinguish AKI from non-AKI. CysC > 1.44 mg/L at admission, both alone (Odds Ratio = 5.04; 95%CI 2.20–11.52; P
ISSN:0278-0240
1875-8630
DOI:10.1155/2015/416059