Efficacy and safety of 1% forskolin eye drops in open angle glaucoma – An open label study

Current treatment for glaucoma includes beta-blockers and prostaglandin analogues which have their own disadvantages. Thus a need exists for new ocular hypotensive agents that are more efficacious and have fewer side effects. Therefore, forskolin eye drops 1%, through herbal product; a clinical tria...

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Bibliographic Details
Published in:Saudi journal of ophthalmology 2015-07, Vol.29 (3), p.197-200
Main Authors: Majeed, Muhammed, Nagabhushanam, Kalyanam, Natarajan, Sankaran, Vaidyanathan, Priti, Karri, Suresh Kumar, Jose, Jyolsna Agnes
Format: Article
Language:English
Subjects:
Hypotensive
Intraocular pressure
Open angle glaucoma
Original
Timolol
Xalatan
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Summary:Current treatment for glaucoma includes beta-blockers and prostaglandin analogues which have their own disadvantages. Thus a need exists for new ocular hypotensive agents that are more efficacious and have fewer side effects. Therefore, forskolin eye drops 1%, through herbal product; a clinical trial was carried out for the safety and efficacy in the treatment of open angle glaucoma. Ninety adult male/female patients of 18–60years of age, of either sex, suffering from open angle glaucoma with an intraocular pressure (IOP) of more than 24mm Hg were enrolled in the study. Patients were advised to instill 2 drops thrice a day (8:00h, 14:00h and 20:00h) and tonometric readings were recorded on baseline visit and on Visit 2, i.e. end of 1st week, Visit 3–2nd week, Visit 4–3rd week, and Visit 5–4th week. The reduction in IOP across each time point from untreated baseline visit and reduction in IOP across various study visits were measured. The mean (95% CI) difference in reduction in IOP was 4.5mm Hg (P
ISSN:1319-4534
DOI:10.1016/j.sjopt.2015.02.003