Telomere length is associated with oppositional defiant behavior and maternal clinical depression in Latino preschool children

Exposure to psychological stress and depression are associated with shorter white blood cell telomere length (TL) in adults, possibly via associated lifelong oxidative stressors. Exposure to maternal depression increases risk for future depression and behavior problems in children, and Latino youth...

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Bibliographic Details
Published in:Translational psychiatry 2015-06, Vol.5 (6), p.e581-e581
Main Authors: Wojcicki, J M, Heyman, M B, Elwan, D, Shiboski, S, Lin, J, Blackburn, E, Epel, E
Format: Article
Language:English
Subjects:
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Adult
Attention Deficit and Disruptive Behavior Disorders - genetics
Behavioral Sciences
Biological Psychology
Child, Preschool
Cohort Studies
Depression - psychology
Depressive Disorder - psychology
Female
Hispanic Americans
Humans
Linear Models
Longitudinal Studies
Male
Medicine
Medicine & Public Health
Mothers - psychology
Multivariate Analysis
Neurosciences
Original
original-article
Paternal Age
Pharmacotherapy
Poverty
Prospective Studies
Psychiatry
Stress, Psychological - genetics
Telomere - genetics
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Summary:Exposure to psychological stress and depression are associated with shorter white blood cell telomere length (TL) in adults, possibly via associated lifelong oxidative stressors. Exposure to maternal depression increases risk for future depression and behavior problems in children, and Latino youth are at high risk. Few studies have evaluated the role of exposure to maternal depression or child behavior in relation to TL in children. We assessed early-childhood exposures to maternal depression from birth to the age of 5 years and child behavior from ages 3–5 years in a cohort of Latino children in relation to child leukocyte TL at ages 4 and 5 years. Children who had oppositional defiant behavior at 3, 4 or 5 years had shorter TL than those without by ~450 base pairs ( P
ISSN:2158-3188
2158-3188
DOI:10.1038/tp.2015.71